Associations of Muscle Density and Area With Coronary Artery Plaque and Physical Function.

Autor:	Erlandson KM; Division of Infectious Diseases, Department of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, CO., Umbleja T; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA., Lu MT; Cardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Taron J; Cardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.; Faculty of Medicine, Department of Radiology, University of Freiburg Medical Center, University of Freiburg, Freiburg, Germany., Ribaudo HJ; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA., Overton ET; Division of Infectious Diseases, University of Alabama at Birmingham School of Medicine, Birmingham, AL., Presti RM; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Haas DW; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.; Department of Internal Medicine, Meharry Medical College, Nashville, TN., Sax PE; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Yin MT; Division of Infectious Diseases, Department of Internal Medicine, Columbia University Irving Medical Center, New York, NY., Zhai BK; Cardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Louis R; Cardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Upadhyay N; Cardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Eslami P; Cardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Douglas PS; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC., Zanni MV; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Fitch KV; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Fulda ES; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Fichtenbaum CJ; Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH., Malvestutto CD; Division of Infectious Diseases, Ohio State University Medical Center, Columbus, OH; and., Grinspoon SK; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Brown TT; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Jazyk:	angličtina
Zdroj:	Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2023 Oct 01; Vol. 94 (2), pp. 174-184.
DOI:	10.1097/QAI.0000000000003244
Abstrakt:	Objective: Skeletal muscle quality and mass are important for maintaining physical function during advancing age. We leveraged baseline data from Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) to evaluate whether paraspinal muscle density and muscle area are associated with cardiac or physical function outcomes in people with HIV (PWH). Methods: REPRIEVE is a double-blind randomized trial evaluating the effect of pitavastatin for primary prevention of major adverse cardiovascular events in PWH. This cross-sectional analysis focuses on participants who underwent coronary computed tomography at baseline. Lower thoracic paraspinal muscle density (Hounsfield units [HU]) and area (cm 2 ) were assessed on noncontrast computed tomography. Results: Of 805 PWH, 708 had paraspinal muscle measurements. The median age was 51 years and 17% were natal female patients. The median muscle density was 41 HU (male) and 30 HU (female); area 13.2 cm 2 /m (male) and 9.9 cm 2 /m (female). In adjusted analyses, greater density (less fat) was associated with a lower prevalence of any coronary artery plaque, coronary artery calcium score >0, and high plaque burden ( P = 0.06); area was not associated with plaque measures. Among 139 patients with physical function measures, greater area (but not density) was associated with better performance on a short physical performance battery and grip strength. Conclusions: Among PWH, greater paraspinal muscle density was associated with a lower prevalence of coronary artery disease while greater area was associated with better physical performance. Whether changes in density or area are associated with changes in CAD or physical performance will be evaluated through longitudinal analyses in REPRIEVE. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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