T-type Ca 2+ and persistent Na + currents synergistically elevate ventral, not dorsal, entorhinal cortical stellate cell excitability.

Autor: Topczewska A; Pharmacology, School of Pharmacy, University College London, London WC1N 4AX, UK., Giacalone E; Institute of Biophysics, National Research Council, 90146 Palermo, Italy., Pratt WS; Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK., Migliore M; Institute of Biophysics, National Research Council, 90146 Palermo, Italy., Dolphin AC; Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK., Shah MM; Pharmacology, School of Pharmacy, University College London, London WC1N 4AX, UK. Electronic address: mala.shah@ucl.ac.uk.
Jazyk: angličtina
Zdroj: Cell reports [Cell Rep] 2023 Jul 25; Vol. 42 (7), pp. 112699. Date of Electronic Publication: 2023 Jun 26.
DOI: 10.1016/j.celrep.2023.112699
Abstrakt: Dorsal and ventral medial entorhinal cortex (mEC) regions have distinct neural network firing patterns to differentially support functions such as spatial memory. Accordingly, mEC layer II dorsal stellate neurons are less excitable than ventral neurons. This is partly because the densities of inhibitory conductances are higher in dorsal than ventral neurons. Here, we report that T-type Ca 2+ currents increase 3-fold along the dorsal-ventral axis in mEC layer II stellate neurons, with twice as much Ca V 3.2 mRNA in ventral mEC compared with dorsal mEC. Long depolarizing stimuli trigger T-type Ca 2+ currents, which interact with persistent Na + currents to elevate the membrane voltage and spike firing in ventral, not dorsal, neurons. T-type Ca 2+ currents themselves prolong excitatory postsynaptic potentials (EPSPs) to enhance their summation and spike coupling in ventral neurons only. These findings indicate that T-type Ca 2+ currents critically influence the dorsal-ventral mEC stellate neuron excitability gradient and, thereby, mEC dorsal-ventral circuit activity.
Competing Interests: Declaration of interests The authors declare no completing interests.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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