Memory B cell development elicited by mRNA booster vaccinations in the elderly.

Autor:	Wang Z; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Muecksch F; Laboratory of Retrovirology, The Rockefeller University , New York, NY, USA.; Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany., Raspe R; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Johannsen F; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Turroja M; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Canis M; Laboratory of Retrovirology, The Rockefeller University , New York, NY, USA., ElTanbouly MA; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Santos GSS; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Johnson B; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Baharani VA; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA.; Laboratory of Retrovirology, The Rockefeller University , New York, NY, USA., Patejak R; Laboratory of Retrovirology, The Rockefeller University , New York, NY, USA., Yao KH; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Chirco BJ; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Millard KG; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Shimeliovich I; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Oliveira TY; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Bieniasz PD; Laboratory of Retrovirology, The Rockefeller University , New York, NY, USA.; Howard Hughes Medical Institute , Maryland, MD, USA., Hatziioannou T; Laboratory of Retrovirology, The Rockefeller University , New York, NY, USA., Caskey M; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA., Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University , New York, NY, USA.; Howard Hughes Medical Institute , Maryland, MD, USA.
Jazyk:	angličtina
Zdroj:	The Journal of experimental medicine [J Exp Med] 2023 Sep 04; Vol. 220 (9). Date of Electronic Publication: 2023 Jun 27.
DOI:	10.1084/jem.20230668
Abstrakt:	Despite mRNA vaccination, elderly individuals remain especially vulnerable to severe consequences of SARS-CoV-2 infection. Here, we compare the memory B cell responses in a cohort of elderly and younger individuals who received mRNA booster vaccinations. Plasma neutralizing potency and breadth were similar between the two groups. By contrast, the absolute number of SARS-CoV-2-specific memory B cells was lower in the elderly. Antibody sequencing revealed that the SARS-CoV-2-specific elderly memory compartments were more clonal and less diverse. Notably, memory antibodies from the elderly preferentially targeted the ACE2-binding site on the RBD, while those from younger individuals targeted less accessible but more conserved epitopes. Nevertheless, individual memory antibodies elicited by booster vaccines in the elderly and younger individuals showed similar levels of neutralizing activity and breadth against SARS-CoV-2 variants. Thus, the relatively diminished protective effects of vaccination against serious disease in the elderly are associated with a smaller number of antigen-specific memory B cells that express altered antibody repertoires. (© 2023 Wang et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu