Distinct inflammatory Th17 subsets emerge in autoimmunity and infection.

Autor:	Bouch RJ; Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biology, Wake Forest University, Winston-Salem, NC, USA., Zhang J; Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Miller BC; Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biology, Wake Forest University, Winston-Salem, NC, USA., Robbins CJ; Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Mosher TH; Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biology, Wake Forest University, Winston-Salem, NC, USA., Li W; Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Krupenko SA; Department of Nutrition, Nutrition Research Institute, University of North Carolina, Kannapolis, NC, USA., Nagpal R; Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL, USA., Zhao J; Florida Research and Innovation Center, Cleveland Clinic, Port St. Lucie, FL, USA., Bloomfeld RS; Department of Gastroenterology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Lu Y; The Methodist Hospital Research Institute , Houston, TX, USA., Nikiforov MA; Department of Pathology, Duke University, Durham, NC, USA., Song Q; Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, USA., He Z; Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jazyk:	angličtina
Zdroj:	The Journal of experimental medicine [J Exp Med] 2023 Oct 02; Vol. 220 (10). Date of Electronic Publication: 2023 Jun 27.
DOI:	10.1084/jem.20221911
Abstrakt:	Th17 cells play a critical role in both tissue homeostasis and inflammation during clearance of infections as well as autoimmune and inflammatory disorders. Despite numerous efforts to distinguish the homeostatic and inflammatory roles of Th17 cells, the mechanism underlying the divergent functions of inflammatory Th17 cells remains poorly understood. In this study, we demonstrate that the inflammatory Th17 cells involved in autoimmune colitis and those activated during colitogenic infection are distinguishable populations characterized by their differential responses to the pharmacological molecule, clofazimine (CLF). Unlike existing Th17 inhibitors, CLF selectively inhibits proautoimmune Th17 cells while preserving the functional state of infection-elicited Th17 cells partially by reducing the enzyme ALDH1L2. Overall, our study identifies two distinct subsets within the inflammatory Th17 compartment with distinct regulatory mechanisms. Furthermore, we highlight the feasibility to develop disease-promoting Th17 selective inhibitor for treating autoimmune diseases. (© 2023 Bouch et al.)
Databáze:	MEDLINE
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