Viral recognition and the antiviral interferon response.

Autor: Dalskov L; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Gad HH; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Hartmann R; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Jazyk: angličtina
Zdroj: The EMBO journal [EMBO J] 2023 Jul 17; Vol. 42 (14), pp. e112907. Date of Electronic Publication: 2023 Jun 27.
DOI: 10.15252/embj.2022112907
Abstrakt: Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response to viral infections. In response to viral stimuli, cells produce and release interferons, which then act on neighboring cells to induce the transcription of hundreds of genes. Many of these gene products either combat the viral infection directly, e.g., by interfering with viral replication, or help shape the following immune response. Here, we review how viral recognition leads to the production of different types of IFNs and how this production differs in spatial and temporal manners. We then continue to describe how these IFNs play different roles in the ensuing immune response depending on when and where they are produced or act during an infection.
(© 2023 Aarhus University. Published under the terms of the CC BY NC ND 4.0 license.)
Databáze: MEDLINE
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