Fluorinated Phthalocyanine/Silver Nanoconjugates for Multifunctional Biological Applications.

Autor: Albayrak S; Chemistry, Istanbul Technical University, Maslak, TR-34469, Istanbul, Türkiye., Farajzadeh N; Chemistry, Istanbul Technical University, Maslak, TR-34469, Istanbul, Türkiye., Yasemin Yenilmez H; Chemistry, Istanbul Technical University, Maslak, TR-34469, Istanbul, Türkiye., Özdemir S; Food Processing Programme, Technical Science Vocational School, University of Mersin, Yenisehir, TR-33343, Mersin, Türkiye., Gonca S; Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Mersin, Yenisehir, TR-33343, Mersin, Türkiye., Altuntaş Bayır Z; Chemistry, Istanbul Technical University, Maslak, TR-34469, Istanbul, Türkiye.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2023 Jul; Vol. 20 (7), pp. e202300389. Date of Electronic Publication: 2023 Jun 27.
DOI: 10.1002/cbdv.202300389
Abstrakt: In this study, a new phthalonitrile derivative namely 4-[(2,4-difluorophenyl)ethynyl]phthalonitrile (1) and its metal phthalocyanines (2 and 3) were synthesized. The resultant compounds were conjugated to silver nanoparticles and characterized using transmission electron microscopy (TEM) images. The biological properties of compounds (1-3), their nanoconjugates (4-6), and silver nanoparticles (7) were examined for the first time in this study. The antioxidant activities of biological candidates (1-7) were studied by applying the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The highest antioxidant activity was obtained 97.47 % for 200 mg/L manganese phthalocyanine-silver nanoconjugates (6). The antimicrobial and antimicrobial photodynamic therapy (APDT) activities of biological candidates (1-7) were examined using a micro-dilution assay. The highest MIC value was obtained 8 mg/L for nanoconjugate 6 against E. hirae. The studied compounds and their silver nanoconjugates exhibited high APDT activities against all the studied microorganisms. The most effective APDT activities were obtained 4 mg/L for nanoconjugates (5 and 6) against L. pneumophila and E. hirae, respectively. All the studied biological candidates displayed high cell viability inhibition activities against E. coli cell growth. The biofilm inhibition activities of the tested biological candidates were also investigated against S. aureus and P. Aeruginosa. Biological candidates (1-6) can be considered efficient metal nanoparticle-based materials for multi-disciplinary biological applications.
(© 2023 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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