Fibroblast Activation Protein-α (FAP) Identifies Stromal Invasion in Colorectal Neoplasia.

Autor:	Tarín-Nieto A; Department of Anatomic Pathology, Basurto University Hospital., Solano-Iturri JD; Department of Anatomic Pathology, Cruces University Hospital, Cruces (Barakaldo).; Biocruces-Bizkaia Health Research Institute, Barakaldo., Arrieta-Aguirre I; Departments of Nursing., Valdivia A; Cell Biology and Histology., Etxezarraga MC; Department of Anatomic Pathology, Basurto University Hospital., Loizate A; Department of Surgery, Basurto University Hospital, University of the Basque Country (UPV/EHU), Bilbao., López JI; Biocruces-Bizkaia Health Research Institute, Barakaldo., Larrinaga G; Biocruces-Bizkaia Health Research Institute, Barakaldo.; Departments of Nursing.; Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Bizkaia Province, Spain.
Jazyk:	angličtina
Zdroj:	The American journal of surgical pathology [Am J Surg Pathol] 2023 Sep 01; Vol. 47 (9), pp. 1027-1033. Date of Electronic Publication: 2023 Jun 27.
DOI:	10.1097/PAS.0000000000002075
Abstrakt:	The increasing detection of colorectal adenomas and early adenocarcinomas (ADCs) in the context of nationwide screening programs has led to a significant increase in the incidence of inconclusive diagnoses in which histopathologic analysis of endoscopic biopsies does not allow pathologists to provide a reliable diagnosis of stromal invasion. The objective of this study was to analyze the discriminative capacity of the immunohistochemical expression of fibroblast activation protein-α (FAP) in distinguishing colorectal adenomas with low-grade dysplasia (LGD) and high-grade dysplasia (HGD) from invasive intestinal-type ADCs. The study analyzed the first endoscopic biopsies from a series of patients classified as inconclusive or conclusive for stromal invasion based on the pathologic report. In total, 30 ADCs, 52 HGDs, and 15 LGDs were included in the study. FAP expression was detected in 23/30 ADCs and was negative in all adenomas with either LGD or HGD features (100% specificity and 76.7% sensitivity, area under the curve=0.883, CI=0.79-0.98). Considering these findings, we conclude that FAP is a potentially useful tool for helping pathologists identify invasive lesions in colorectal endoscopic biopsies, avoiding unnecessary biopsy repetitions. Competing Interests: Conflicts of Interest and Source of Funding: This project was partially funded by a grant from the University of the Basque Country (UPV/EHU) (PES22/102). The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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