Involvement of the genus Corynebacterium in the pathogenesis of pigmented intratarsal keratinous cyst.

Autor: Yoshikawa M; Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Rokunohe D; Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Takahashi M; Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Korekawa A; Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Nakajima K; Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Nakano H; Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Akemoto Y; Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Kurose A; Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Sawamura D; Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Jazyk: angličtina
Zdroj: The Journal of dermatology [J Dermatol] 2023 Nov; Vol. 50 (11), pp. 1488-1492. Date of Electronic Publication: 2023 Jun 27.
DOI: 10.1111/1346-8138.16871
Abstrakt: Intratarsal keratinous cyst (IKC) is a benign cystic lesion of the eyelid that retains keratin flakes. IKCs are usually yellow to white cystic lesions but rarely become brown or gray-blue, making clinical diagnosis difficult. The mechanisms by which dark brown pigments are generated in pigmented IKC are unclear. The authors report a case of pigmented IKC that had melanin pigments within the lining of the cyst wall and within the cyst. Focal infiltrates of lymphocytes were observed in the dermis, particularly beneath the cyst wall in areas with more melanocytes and intense melanin deposition. These pigmented parts faced bacterial colonies inside the cyst, which were identified to be Corynebacterium species in a bacterial flora analysis. The pathogenesis of pigmented IKC in relation to inflammation and bacterial flora is discussed.
(© 2023 Japanese Dermatological Association.)
Databáze: MEDLINE
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