Adaptability of melanocytes post ultraviolet stimulation in patients with melasma.

Autor:	Wang YJ; Department of Dermatology, MacKay Memorial Hospital, Taipei, Taiwan.; Department of Cosmetic Applications and Management, MacKay Junior College of Medicine, Nursing, and Management, New Taipei City, Taiwan., Chang CC; Department of Cosmeceutics, China Medical University, Taichung, Taiwan.; Institute of Imaging and Biomedical Photonics, National Yang Ming Chiao Tung University, Tainan, Taiwan.; School of Medicine, College of Medicine, China Medical University Hospital, Taichung, Taiwan.; Aesthetic Medical Center, China Medical University Hospital, Taichung, Taiwan., Wu YH; Department of Dermatology, MacKay Memorial Hospital, Taipei, Taiwan.; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan., Huang L; Clinical Development, Apollo Medical Optics, Ltd., Taipei, Taiwan., Shen JW; Department of Cosmeceutics, China Medical University, Taichung, Taiwan., Lu ME; Department of Cosmeceutics, China Medical University, Taichung, Taiwan., Chiang HM; Department of Cosmeceutics, China Medical University, Taichung, Taiwan., Lin BS; Institute of Imaging and Biomedical Photonics, National Yang Ming Chiao Tung University, Tainan, Taiwan.
Jazyk:	angličtina
Zdroj:	Lasers in surgery and medicine [Lasers Surg Med] 2023 Sep; Vol. 55 (7), pp. 680-689. Date of Electronic Publication: 2023 Jun 27.
DOI:	10.1002/lsm.23699
Abstrakt:	Background: Dynamic in vivo changes in melanin in melasma lesions after exposure to ultraviolet (UV) irradiation have not been described. Objectives: To determine whether melasma lesions and nearby perilesions demonstrated different adaptive responses to UV irradiation and whether the tanning responses were different among different locations on face. Methods: We collected sequential images from real-time cellular resolution full-field optical coherence tomography (CRFF-OCT) at melasma lesions and perilesions among 20 Asian patients. Quantitative and layer distribution analyses for melanin were performed using a computer-aided detection (CADe) system that utilizes spatial compounding-based denoising convolutional neural networks. Results: The detected melanin (D) is melanin with a diameter >0.5 µm, among which confetti melanin (C) has a diameter of >3.3 µm and corresponds to a melanosome-rich package. The calculated C/D ratio is proportional to active melanin transportation. Before UV exposure, melasma lesions had more detected melanin (p = 0.0271), confetti melanin (p = 0.0163), and increased C/D ratio (p = 0.0152) in the basal layer compared to those of perilesions. After exposure to UV irradiation, perilesions have both increased confetti melanin (p = 0.0452) and the C/D ratio (p = 0.0369) in basal layer, and this effect was most prominent in right cheek (p = 0.030). There were however no significant differences in the detected, confetti, or granular melanin areas before and after exposure to UV irradiation in melasma lesions in all the skin layers. Conclusions: Hyperactive melanocytes with a higher baseline C/D ratio were noted in the melasma lesions. They were "fixed" on the plateau and were not responsive to UV irradiation regardless of the location on face. Perilesions retained adaptability with a dynamic response to UV irradiation, in which more confetti melanin was shed, mainly in the basal layer. Therefore, aggravating effect of UV on melasma was mainly due to UV-responsive perilesions rather than lesions. (© 2023 Wiley Periodicals LLC.)
Databáze:	MEDLINE
Externí odkaz:	Plný text