Beneficial effects of metformin on mice female fertility after a high-fat diet intake.

Autor: Velazquez C; Instituto de Biología y Medicina Experimental, IByME-CONICET, Vuelta de Obligado 2490, C1428ADL Ciudad Autónoma de Buenos Aires, Argentina., Herrero Y; Instituto de Biología y Medicina Experimental, IByME-CONICET, Vuelta de Obligado 2490, C1428ADL Ciudad Autónoma de Buenos Aires, Argentina., Bianchi MS; Instituto de Biología y Medicina Experimental, IByME-CONICET, Vuelta de Obligado 2490, C1428ADL Ciudad Autónoma de Buenos Aires, Argentina., Cohen DJ; Instituto de Biología y Medicina Experimental, IByME-CONICET, Vuelta de Obligado 2490, C1428ADL Ciudad Autónoma de Buenos Aires, Argentina., Cuasnicu P; Instituto de Biología y Medicina Experimental, IByME-CONICET, Vuelta de Obligado 2490, C1428ADL Ciudad Autónoma de Buenos Aires, Argentina., Prost K; Hospital Interzonal General de Agudos Pedro Fiorito, sector de Endocrinología, Av. Manuel Belgrano 827, B1870 Avellaneda, Provincia de Buenos Aires, Argentina., Marinoni R; Instituto de Biología y Medicina Experimental, IByME-CONICET, Vuelta de Obligado 2490, C1428ADL Ciudad Autónoma de Buenos Aires, Argentina., Pascuali N; Instituto de Biología y Medicina Experimental, IByME-CONICET, Vuelta de Obligado 2490, C1428ADL Ciudad Autónoma de Buenos Aires, Argentina; Department of Pathology, College of Medicine, University of Illinois at Chicago (UIC), Chicago, IL, United States., Parborell F; Instituto de Biología y Medicina Experimental, IByME-CONICET, Vuelta de Obligado 2490, C1428ADL Ciudad Autónoma de Buenos Aires, Argentina., Abramovich D; Instituto de Biología y Medicina Experimental, IByME-CONICET, Vuelta de Obligado 2490, C1428ADL Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: dnabramovich@gmail.com.
Jazyk: angličtina
Zdroj: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2023 Sep 15; Vol. 575, pp. 111995. Date of Electronic Publication: 2023 Jun 25.
DOI: 10.1016/j.mce.2023.111995
Abstrakt: Female fertility is highly dependent on energy balance. High fat diet (HFD) intake entails a risk of infertility and ovulatory disorders. Considering the increase in the prevalence of overweight and obesity over the last decades, it is crucial to understand the mechanisms involved in overweight-associated infertility. In this study, we evaluated the reproductive performance of female mice fed with a HFD and the effects of metformin administration on ovarian function in these mice. We hypothesized that one of the mechanisms involved in subfertility due to a HFD intake is the alteration of ovarian blood vessel formation. We found that mice fed with HFD had altered estrous cycles and steroidogenesis, increased ovarian fibrosis, fewer pups per litter and require more time to achieve pregnancy. HFD-fed mice also presented dysregulated ovarian angiogenesis and an increase in nuclear DNA damage in ovarian cells. Ovulation rates were lower in these animals, as evidenced both in natural mating and after ovulation induction with gonadotropins. Metformin ameliorated ovarian angiogenesis, improved steroidogenesis, fibrosis, and ovulation, decreased the time to pregnancy and increased litter sizes in HFD-fed mice. We conclude that ovarian angiogenesis is one of the mechanisms detrimentally affected by HFD intake. Since metformin could improve ovarian microvasculature, it may be an interesting strategy to study in women to shed light on new targets for patients with metabolic disturbances.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dalhia Abramovich reports financial support was provided by National Scientific and Technical Research Council.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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