Cardiac Xenotransplantation: Barriers, Future Directions, and Ethical Considerations.
| Autor: | Whiteson HZ; From the New York Medical College, School of Medicine, Valhalla, NY., Frishman WH; Department of Medicine, New York Medical College, Valhalla, NY. |
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| Jazyk: | angličtina |
| Zdroj: | Cardiology in review [Cardiol Rev] 2023 Jun 26. Date of Electronic Publication: 2023 Jun 26. |
| DOI: | 10.1097/CRD.0000000000000562 |
| Abstrakt: | Since data collection began in 1995, 12,713 people have died while waiting for a heart transplant. Combined with a significant number of individuals with end-stage organ disease-eligible and waiting to receive a transplant offer-is a critical shortage of registered organ donors and acceptable organs. Strategies to overcome this organ shortage include efforts to increase the number of individuals registered as donors as well as new therapeutic approaches to managing organs that would have been otherwise deemed unacceptable for donation. One emerging technology that has the potential to further alleviate the demand for organs is xenotransplantation, where genetically engineered animal tissue or organ is transplanted into a human patient. While still in its elementary phases, this method shows great promise in reducing transplant wait-time and ultimately improving the quality of life and survival rate of transplant recipient patients. In 2021-2022, researchers at the University of Maryland Medical Center performed the first pig-to-human cardiac xenotransplantation on a live recipient. This review analyzes the case and discusses barriers, future directions, and ethical considerations to implementing cardiac xenotransplantation as a standard of care. Competing Interests: Disclosure: The authors declare no conflict of interest. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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