Li-Fraumeni syndrome in the setting of re-occurring malignancies after 27 years of remission: a case report.

Autor:	Mousa AH; College of Medicine and Surgery, Batterjee Medical College, Jeddah, Saudi Arabia., Ibrahim AS; College of Medicine and Surgery, Batterjee Medical College, Jeddah, Saudi Arabia., Alsayed AW; College of Medicine and Surgery, Batterjee Medical College, Jeddah, Saudi Arabia., Albukhari ZZ; College of Medicine and Surgery, Batterjee Medical College, Jeddah, Saudi Arabia., Mogharbel A; Ibn Siena National College, Medicine and Surgery., Alshanberi AM; College of Medicine and Surgery, Batterjee Medical College, Jeddah, Saudi Arabia.; Department of Community Medicine and Pilgrims Health Care, Umm Al-Qura University, Makkah., Albar NY; Dr. Samir Abbas Hospital, Jeddah, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2023 Apr 27; Vol. 85 (6), pp. 3012-3016. Date of Electronic Publication: 2023 Apr 27 (Print Publication: 2023).
DOI:	10.1097/MS9.0000000000000724
Abstrakt:	Multiple primary tumors are defined as multiple simultaneous (within 6 months) or heterogeneous tumors. Case Presentation: Here, the authors present the case of a 58-year-old Saudi female patient with Li-Fraumeni syndrome who has multiple primary tumors. Clinical Discussion: The surgical cytoreduction or 'debulking' technique is the main treatment option started in individuals with High Grade Serous Ovarian CanceR. This surgical strategy aims to completely remove all disseminated tumor masses that are present in the patient's peritoneal cavity on a macroscopic level. Conclusion: In conclusion, in our case, she has developed her ovarian cancer 27 years after her breast cancer got treated. This was already stage IIIB to stage IV. If it was not for her incidental discovery of her urinary bladder cancer, which is most likely is a long-term sequel of using cyclophosphamide 27 years ago.Multiple primary tumors are defined as multiple simultaneous (within 6 months) or heterogeneous tumors. Here, the authors present the case of a 58-year-old Saudi female patient with Li-Fraumeni syndrome who has multiple primary tumors. In conclusion, in our case, she has developed her ovarian cancer 27 years after her breast cancer got treated. This was already stage IIIB to stage IV. If it was not for her incidental discovery of her urinary bladder cancer, which is most likely is a long-term sequel of using cyclophosphamide 27 years ago. Competing Interests: NA. (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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