Immunoglobulin A nephropathy associated with acute hepatitis E infection: First case report.
| Autor: | Cheema SS; Head Department of Nephrology, Jinnah Hospital Lahore, Usmani Rd, Quaid-i-Azam Campus, Lahore, Punjab, Pakistan., Cheema MF; Head Department of Nephrology, Jinnah Hospital Lahore, Usmani Rd, Quaid-i-Azam Campus, Lahore, Punjab, Pakistan., Gilani S; Head Department of Nephrology, Jinnah Hospital Lahore, Usmani Rd, Quaid-i-Azam Campus, Lahore, Punjab, Pakistan., Cheema SR; Head Department of Nephrology, Jinnah Hospital Lahore, Usmani Rd, Quaid-i-Azam Campus, Lahore, Punjab, Pakistan. |
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| Jazyk: | angličtina |
| Zdroj: | Clinical nephrology. Case studies [Clin Nephrol Case Stud] 2023 Jun 08; Vol. 11, pp. 95-98. Date of Electronic Publication: 2023 Jun 08 (Print Publication: 2023). |
| DOI: | 10.5414/CNCS111100 |
| Abstrakt: | In this case report, we describe a young male patient who presented with gross hematuria and nephrotic syndrome a few weeks after serologically positive acute hepatitis E virus (HEV) infection. Histopathological examination of renal core biopsy revealed that the majority of the viable glomeruli had a predominantly mesangiopathic process characterized by mild to moderate diffuse increase in mesangial matrix and cellularity with segmental variation. Immunofluorescence microscopy depicted a strong (3+) granular mesangial and capillary loop staining for IgA, consistent with IgA nephropathy (IgAN). This pattern of mesangial and glomerular capillary loop staining of IgA is suggestive of secondary IgAN. Further research is required to explore the relationship between IgAN and acute HEV infection. Competing Interests: The authors have no conflict of interest to disclose. Figure 1.Glomeruli exhibit mild-moderate degree of mesangial hypercellularity and matrix increase; light microscopy (H & E stain, original magnification × 400).Figure 2.One of the globally sclerosed glomeruli; light microscopy (PAS stain, original magnification × 100).Figure 3.Mesangial and capillary wall IgA deposits (immunofluorescence staining for IgA, original magnification × 400). (© Dustri-Verlag Dr. K. Feistle.) |
| Databáze: | MEDLINE |
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