Six-lead electrocardiography compared to single-lead electrocardiography and photoplethysmography of a wrist-worn device for atrial fibrillation detection controlled by premature atrial or ventricular contractions: six is smarter than one.

Autor:	Bacevicius J; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Taparauskaite N; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Kundelis R; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Sokas D; Biomedical Engineering Institute, Kaunas University of Technology, Kaunas, Lithuania., Butkuviene M; Biomedical Engineering Institute, Kaunas University of Technology, Kaunas, Lithuania., Stankeviciute G; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania., Abramikas Z; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Pilkiene A; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania., Dvinelis E; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Staigyte J; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Marinskiene J; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Audzijoniene D; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Petrylaite M; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Jukna E; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Karuzas A; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Juknevicius V; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Jakaite R; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Basyte-Bacevice V; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania., Bileisiene N; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Badaras I; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Kiseliute M; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania., Zarembaite G; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania., Gudauskas M; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Jasiunas E; Center of Informatics and Development, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania., Johnson L; Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden., Marozas V; Biomedical Engineering Institute, Kaunas University of Technology, Kaunas, Lithuania.; Electronics Engineering Department, Kaunas University of Technology, Kaunas, Lithuania., Aidietis A; Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.; Center of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2023 Jun 09; Vol. 10, pp. 1160242. Date of Electronic Publication: 2023 Jun 09 (Print Publication: 2023).
DOI:	10.3389/fcvm.2023.1160242
Abstrakt:	Background: Smartwatches are commonly capable to record a lead-I-like electrocardiogram (ECG) and perform a photoplethysmography (PPG)-based atrial fibrillation (AF) detection. Wearable technologies repeatedly face the challenge of frequent premature beats, particularly in target populations for screening of AF. Objective: To investigate the potential diagnostic benefit of six-lead ECG compared to single-lead ECG and PPG-based algorithm for AF detection of the wrist-worn device. Methods and Results: From the database of DoubleCheck-AF 249 adults were enrolled in AF group ( n  = 121) or control group of SR with frequent premature ventricular (PVCs) or atrial (PACs) contractions ( n  = 128). Cardiac rhythm was monitored using a wrist-worn device capable of recording continuous PPG and simultaneous intermittent six-lead standard-limb-like ECG. To display a single-lead ECG, the six-lead ECGs were trimmed to lead-I-like ECGs. Two diagnosis-blinded cardiologists evaluated reference, six-lead and single-lead ECGs as "AF", "SR", or "Cannot be concluded". AF detection based on six-lead ECG, single-lead ECG, and PPG yielded a sensitivity of 99.2%, 95.7%, and 94.2%, respectively. The higher number of premature beats per minute was associated with false positive outcomes of single-lead ECG (18.80 vs. 5.40 beats/min, P  < 0.01), six-lead ECG (64.3 vs. 5.8 beats/min, P  = 0.018), and PPG-based detector (13.20 vs. 5.60 beats/min, P  = 0.05). Single-lead ECG required 3.4 times fewer extrasystoles than six-lead ECG to result in a false positive outcome. In a control subgroup of PACs, the specificity of six-lead ECG, single-lead ECG, and PPG dropped to 95%, 83.8%, and 90%, respectively. The diagnostic value of single-lead ECG (AUC 0.898) was inferior to six-lead ECG (AUC 0.971) and PPG-based detector (AUC 0.921). In a control subgroup of PVCs, the specificity of six-lead ECG, single-lead ECG, and PPG was 100%, 96.4%, and 96.6%, respectively. The diagnostic value of single-lead ECG (AUC 0.961) was inferior to six-lead ECG (AUC 0.996) and non-inferior to PPG-based detector (AUC 0.954). Conclusions: A six-lead wearable-recorded ECG demonstrated the superior diagnostic value of AF detection compared to a single-lead ECG and PPG-based AF detection. The risk of type I error due to the widespread use of smartwatch-enabled single-lead ECGs in populations with frequent premature beats is significant. Competing Interests: JB, DS, MB, VM, AA hold patent for the technology. JB received travel grants from Abbot, consults Teltonika Telemedic, received travel grants from Biosense Webster. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 Bacevicius, Taparauskaite, Kundelis, Sokas, Butkuviene, Stankeviciute, Abramikas, Pilkiene, Dvinelis, Staigyte, Marinskiene, Audzijoniene, Petrylaite, Jukna, Karuzas, Juknevicius, Jakaite, Basyte-Bacevice, Bileisiene, Badaras, Kiseliute, Zarembaite, Gudauskas, Jasiunas, Johnson, Marozas and Aidietis.)
Databáze:	MEDLINE
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