Increased Vertebral Gallium-68-DOTATATE Activity on Positron Emission Tomography-Computed Tomography in Merkel Cell Carcinoma: Not Always Metastasis.
| Autor: | Purohit K; Radiology, Stony Brook University Hospital, Stony Brook, USA., Minassian G; Radiology, Stony Brook University Hospital, Stony Brook, USA., Purohit L; Internal Medicine, Broward Health Medical Center, Fort Lauderdale, USA., Peyster R; Radiology, Stony Brook University Hospital, Stony Brook, USA., Bluestone A; Radiology, Stony Brook University Hospital, Stony Brook, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 May 24; Vol. 15 (5), pp. e39427. Date of Electronic Publication: 2023 May 24 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.39427 |
| Abstrakt: | Merkel cell carcinoma (MCC) is a rare neuroendocrine dermal malignancy seen in elderly light-skinned individuals, associated with immunosuppression and Merkel cell polyomavirus infection. As a neuroendocrine tumor, the recurrence and metastasis of MCC can be evaluated using positron emission tomography-computed tomography (PET-CT) with the Gallium-68-DOTATATE (Ga-68-DOTATATE) radiotracer, which has demonstrated increased sensitivity to neuroendocrine metastases when compared to F-18 fluorodeoxyglucose (FDG). Here, we present the case of a patient with known metastatic MCC with a new, abnormal focus of increased radiotracer activity in the thoracic spine on Ga-68-DOTATATE PET-CT suspected to represent a metastatic lesion. Further evaluation with MRI revealed a benign vertebral hemangioma, highlighting the limitations of this radiotracer in the setting of benign spinal lesions. Multimodality imaging findings of metastatic MCC and potential pitfalls of Ga-68-DOTATATE PET-CT staging are discussed. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Purohit et al.) |
| Databáze: | MEDLINE |
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