Gestational Mild COVID-19 Infection Associated Neonatal Hearing Loss: A Case-Control Study from North India.

Autor: Rajanna LB; Cariappa Road, Lucknow, Uttar Pradesh 226002 India Department of ENT, Head and Neck Surgery, Command Hospital Central Command., Raina S; Cariappa Road, Lucknow, Uttar Pradesh 226002 India Department of ENT, Head and Neck Surgery, Command Hospital Central Command., Bhatia R; Cariappa Road, Lucknow, Uttar Pradesh 226002 India Department of ENT, Head and Neck Surgery, Command Hospital Central Command., Tripathi S; Cariappa Road, Lucknow, Uttar Pradesh 226002 India Department of ENT, Head and Neck Surgery, Command Hospital Central Command., Bayad HC; Cariappa Road, Lucknow, Uttar Pradesh 226002 India Department of ENT, Head and Neck Surgery, Command Hospital Central Command., Ranjan R; Cariappa Road, Lucknow, Uttar Pradesh 226002 India Department of ENT, Head and Neck Surgery, Command Hospital Central Command., Srivastava A; Cariappa Road, Lucknow, Uttar Pradesh 226002 India Department of ENT, Head and Neck Surgery, Command Hospital Central Command., Chahar OS; Cariappa Road, Lucknow, Uttar Pradesh 226002 India Department of ENT, Head and Neck Surgery, Command Hospital Central Command.
Jazyk: angličtina
Zdroj: Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India [Indian J Otolaryngol Head Neck Surg] 2023 Apr 17, pp. 1-6. Date of Electronic Publication: 2023 Apr 17.
DOI: 10.1007/s12070-023-03786-2
Abstrakt: COVID-19 infection during pregnancy is potentially dangerous to neonatal hearing, as it is the period of organogenesis, and associated hyperthermia may cause vascular damage, disruption of cell migration, and death of the dividing neuroblasts. To investigate the possible association between neonatal hearing loss and gestational mild COVID-19 infection. A prospective case-control study was conducted at a tertiary healthcare centre in North India from March 2020 to Oct 2022. Cases included the neonates born to COVID-19-positive mothers were subjected to hearing screening at 1, 3 and 6 months using otoacoustic emission (OAE) and automated auditory brainstem response (AABR). Similar protocol was applied to controls, i.e., neonates borne to mothers with no gestational history of COVID infection. Results were analyzed statistically. Our study reported that the statistical difference between groups A (n = 942) and B (n = 942) for gestational COVID-19 infection and neonatal hearing loss was insignificant at 1 month ( p -value 0.272 for OAE and p -value 0.634 for AABR) and also insignificant at 3 and 6 months ( p -value 0.679 for AABR, for both). The association between gestational mild COVID-19 infection during gestation and neonatal hearing loss is statistically insignificant at initial screening as well as sequential screenings.
Competing Interests: Conflict of interestThe authors declare that there is no conflict of interest.
(© Association of Otolaryngologists of India 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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