Microscopic colitis is a risk factor for low bone density: a systematic review and meta-analysis.

Autor:	Rancz A; Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.; Department of Internal Medicine and Hematology, Medical School, Semmelweis University, Budapest, Hungary., Teutsch B; Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary., Engh MA; Centre for Translational Medicine, Semmelweis University, Budapest, Hungary., Veres DS; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary., Földvári-Nagy L; Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary., Erőss B; Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.; Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary., Hosszúfalusi N; Department of Internal Medicine and Hematology, Semmelweis University, Medical School, Budapest, Hungary., Juhász MF; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.; Heim Pál National Pediatric Institute, Budapest, Hungary., Hegyi P; Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.; Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary., Mihály E; Department of Internal Medicine and Hematology, Semmelweis University, Medical School, Szentkirályi Street 46, Budapest 1088, Hungary.
Jazyk:	angličtina
Zdroj:	Therapeutic advances in gastroenterology [Therap Adv Gastroenterol] 2023 Jun 15; Vol. 16, pp. 17562848231177151. Date of Electronic Publication: 2023 Jun 15 (Print Publication: 2023).
DOI:	10.1177/17562848231177151
Abstrakt:	Background: Microscopic colitis (MC) is a chronic inflammatory disease of the large bowel characterized by watery diarrhea, substantially decreasing the patient's quality of life. Scarce data suggest that MC is associated with low bone density (LBD). Objectives: We aimed to assess whether MC is a risk factor for LBD and the proportion of patients with MC having LBD. Design: A systematic review and meta-analysis of studies reporting bone density measurements in MC patients. Data Sources and Methods: We systematically searched five databases from inception to October 16, 2021 (Pubmed, Embase, Cochrane, Scopus, and Web of Science). We used the random-effect model to calculate pooled odds ratios (ORs) and pooled event rates with 95% confidence intervals (CIs). To ascertain the quality of evidence of our outcomes, we followed the recommendations of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) Working Group. Results: The systematic search yielded a total of 3046 articles. Four articles were eligible for quantitative synthesis. All of them used age- and sex-matched controls to evaluate LBD occurrence among patients with MC. The odds of having LBD were twofold increased (OR = 2.13, CI: 1.42-3.20) in the presence of MC, the odds of osteopenia occurrence were 2.4 (OR = 2.45, CI: 1.11-5.41), and of osteoporosis 1.4 (OR = 1.42, CI: 0.65-3.12). The proportion of LBD was 0.68 (CI: 0.56-0.78), osteopenia was 0.51 (CI: 0.43-0.58), and osteoporosis was 0.11 (CI: 0.07-0.16) among the MC population. Our findings' certainty of the evidence was very low following the GRADEPro guideline. Conclusion: Our data demonstrate that MC is associated with a twofold risk for LBD. Based on our findings, we suggest screening patients for bone mineral density upon diagnosis of MC. Further prospective studies with higher patient numbers and longer follow-up periods on this topic are needed. Registration: Our protocol was prospectively registered with PROSPERO (CRD42021283392). Competing Interests: The authors declare that there is no conflict of interest. (© The Author(s), 2023.)
Databáze:	MEDLINE
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