The Evaluation and Management of Visceral Complications in Radiation Fibrosis Syndrome Part 1.

Autor: Jacob RA; Philadelphia, USA.; Northwell Health, Lake Success, NY USA., Bade B; Northwell Health, Lake Success, NY USA., Joffe L; Northwell Health, Lake Success, NY USA., Makkar P; Northwell Health, Lake Success, NY USA., Alfano CM; Northwell Health, Lake Success, NY USA.
Jazyk: angličtina
Zdroj: Current physical medicine and rehabilitation reports [Curr Phys Med Rehabil Rep] 2023 Mar 28, pp. 1-14. Date of Electronic Publication: 2023 Mar 28.
DOI: 10.1007/s40141-023-00391-w
Abstrakt: Abstract: External beam ionizing radiation is a fundamental component of cancer treatment and is incorporated into approximately 50% of cancer treatments. Radiation therapy causes cell death directly by apoptosis and indirectly by disruption of mitosis.
Purpose of Review: This study aims to inform rehabilitation clinicians of the visceral toxicities of radiation fibrosis syndrome and how to detect and diagnose these complications.
Recent Findings: Latest research indicates that radiation toxicity is primarily related to radiation dose, patient co-morbidity, and concomitant use of chemotherapies and immunotherapies for the treatment of cancer. While cancer cells are the primary target, surrounding normal cells and tissues are also affected. Radiation toxicity is dose dependent, and tissue injury develops from inflammation that may progress to fibrosis. Thus, radiation dosing in cancer therapy is often limited by tissue toxicity. Although newer radiotherapeutic modalities aim to limit delivery of radiation to non-cancerous tissues, many patients continue to experience toxicity.
Summary: To ensure early recognition of radiation toxicity and fibrosis, it is imperative that all clinicians are aware of the predictors, signs, and symptoms of radiation fibrosis syndrome. Here, we present part 1 of the visceral complications of radiation fibrosis syndrome, addressing radiation-related toxicity in the heart, lungs, and thyroid gland.
Competing Interests: Conflict of InterestThe authors declare no competing interests.
(© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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