Prevalence of vitamin D deficiency and association with parathyroid hormone.

Autor:	Ravelo Marrero AJ; Clinical Chemist, Hospital Ramón y Cajal, Madrid, Spain., Guillén Astete CA; Rheumatologist, Hospital Ramón y Cajal, Madrid, Spain., Román MM; Clinical Chemist, Hospital Ramón y Cajal, Madrid, Spain., Coronado MR; Clinical Chemist, Hospital Ramón y Cajal, Madrid, Spain., Del Rey Sánchez JM; Clinical Chemist, Hospital Ramón y Cajal, Madrid, Spain., Lozano AG; Clinical Chemist, Hospital Ramón y Cajal, Madrid, Spain., Terán Tinedo MA; Clinical Chemist, Hospital Ramón y Cajal, Madrid, Spain., Díaz MV; Rheumatologist, Hospital Ramón y Cajal, Madrid, Spain., Gómez IA; Clinical Chemist, Hospital Ramón y Cajal, Madrid, Spain.
Jazyk:	English; Spanish; Castilian
Zdroj:	Advances in laboratory medicine [Adv Lab Med] 2022 Jan 05; Vol. 3 (1), pp. 51-66. Date of Electronic Publication: 2022 Jan 05 (Print Publication: 2022).
DOI:	10.1515/almed-2021-0078
Abstrakt:	Objectives: We evaluated the prevalence of 25-hydroxyvitamin D (25-(OH)D) deficiency in our setting according to season, sex, and age. We also studied the association with parathyroid hormone (PTH) levels. Methods: The study population comprised all patients with requests for assessment of 25-(OH)D between January 1 and December 31, 2018, as registered in the database of the laboratory information system. Major exclusion criteria were pediatric samples (<18 years) and factors affecting 25-(OH)D and/or PTH levels (i.e., kidney injury, liver disease, PTH disorders). Results: Among 33,601 patients (24,028 women, 9,573 men), the prevalence of 25-(OH)D deficiency was 48%. Prevalence was greater in males than in females (53% vs. 46%). By age group, deficiency was more prevalent in quartile 1 (Q1, 74-87 years) and less prevalent in quartile 2 (Q2, 60-73 years). By season, deficiency was greater in spring (nonsignificant differences with respect to winter) and lower in summer. The association between 25-(OH)D and PTH was assessed in 9,368 persons. Linear regression analysis showed a weak association (coefficient - 0.303). Multiple logistic regression analysis revealed a significant association between 25-(OH)D deficiency and increased PTH (Odds ratio (OR), 1.63). Other risk factors for increased PTH include female sex (OR, 1.27), season (winter, OR 1.63, spring OR 1.16), and age (quartile 1, OR, 3). Conclusions: The prevalence of 25-(OH)D deficiency differed according to sex, age, and season of the year. Furthermore, elevation of PTH is mainly influenced by low 25-(OH)D, female sex, season, and age. Competing Interests: Competing interests: Authors state no conflict of interest. (© 2021 Alejandro José Ravelo Marrero et al., published by De Gruyter, Berlin/Boston.)
Databáze:	MEDLINE
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