'ACOPP' chemotherapy for older and less fit patients with Hodgkin lymphoma-A multicentre, retrospective study.

Autor: Wilson MR; Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK., Haynes E; Department of Haematology, Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, UK., Parsons K; Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK., Hopkins D; Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK., Robertson E; Department of Haematology, Royal United Hospital Bath NHS Trust, Bath, UK., Ferguson G; Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK., Quinn D; Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK., Murray J; Department of Haematology, Royal United Hospital Bath NHS Trust, Bath, UK., Osborne W; Department of Haematology, Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, UK., Leach M; Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK., McKay P; Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK.
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2023 Aug; Vol. 202 (4), pp. 796-800. Date of Electronic Publication: 2023 Jun 25.
DOI: 10.1111/bjh.18947
Abstrakt: Management of classical Hodgkin lymphoma in older patients is challenging due to poor tolerance of the chemotherapy regimens used in younger patients. We modified the BEACOPP regimen (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine and prednisolone), whereby bleomycin and etoposide were removed and cyclophosphamide dose was reduced, for older patients with co-morbidities. Here we present data from the first 41 patients treated with 'ACOPP' across 3 centres, demonstrating that it can be delivered, with a favourable toxicity profile (TRM 2%) and promising efficacy (2-year PFS and OS, 73% (95% CI: 52-94) and 93% (95% CI: 80-100) respectively).
(© 2023 British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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