Implantable, Bioresorbable Radio Frequency Resonant Circuits for Magnetic Resonance Imaging.

Autor: Lee G; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA., Does MD; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Avila R; Department of Mechanical Engineering, Northwestern University, Evanston, IL, 60208, USA., Kang J; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea., Harkins KD; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Wu Y; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA., Banks WE; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA., Park M; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA., Lu D; School of Microelectronics, University of Science and Technology of China, Hefei, Anhui, 230026, China., Yan X; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Kim JU; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA., Won SM; Department of Electrical and Computer Engineering, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do, 16419, Republic of Korea., Evans AG; Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Joseph JT; Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Kalmar CL; Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Pollins AC; Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Karagoz H; Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Thayer WP; Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Huang Y; Department of Mechanical Engineering, Northwestern University, Evanston, IL, 60208, USA., Rogers JA; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA.; Department of Mechanical Engineering, Northwestern University, Evanston, IL, 60208, USA.; Department of Materials Science and Engineering, Department of Biomedical Engineering, Department of Neurological Surgery, Northwestern University, Evanston, IL, 60208, USA.
Jazyk: angličtina
Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Jul; Vol. 11 (27), pp. e2301232. Date of Electronic Publication: 2023 Jun 25.
DOI: 10.1002/advs.202301232
Abstrakt: Magnetic resonance imaging (MRI) is widely used in clinical care and medical research. The signal-to-noise ratio (SNR) in the measurement affects parameters that determine the diagnostic value of the image, such as the spatial resolution, contrast, and scan time. Surgically implanted radiofrequency coils can increase SNR of subsequent MRI studies of adjacent tissues. The resulting benefits in SNR are, however, balanced by significant risks associated with surgically removing these coils or with leaving them in place permanently. As an alternative, here the authors report classes of implantable inductor-capacitor circuits made entirely of bioresorbable organic and inorganic materials. Engineering choices for the designs of an inductor and a capacitor provide the ability to select the resonant frequency of the devices to meet MRI specifications (e.g., 200 MHz at 4.7 T MRI). Such devices enhance the SNR and improve the associated imaging capabilities. These simple, small bioelectronic systems function over clinically relevant time frames (up to 1 month) at physiological conditions and then disappear completely by natural mechanisms of bioresorption, thereby eliminating the need for surgical extraction. Imaging demonstrations in a nerve phantom and a human cadaver suggest that this technology has broad potential for post-surgical monitoring/evaluation of recovery processes.
(© 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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