Baseline glucose levels moderate the association between burn-related mortality inpatients with obesity.

Autor: Grossman H; Department of Surgery, Texas Tech University Health Science Center, Lubbock, TX, USA., Cole TJ; Clinical Research Data Warehouse, Texas Tech University Health Sciences Center, Lubbock, USA., Shaw C; Clinical Research Data Warehouse, Texas Tech University Health Sciences Center, Lubbock, USA., Dissanaike S; Department of Surgery, Texas Tech University Health Science Center, Lubbock, TX, USA., Dhanasekara CS; Department of Surgery, Texas Tech University Health Science Center, Lubbock, TX, USA. Electronic address: Samudani.Dhanasekara@ttuhsc.edu.
Jazyk: angličtina
Zdroj: Burns : journal of the International Society for Burn Injuries [Burns] 2023 Dec; Vol. 49 (8), pp. 1893-1899. Date of Electronic Publication: 2023 May 16.
DOI: 10.1016/j.burns.2023.05.013
Abstrakt: Background: Differing findings concerning outcomes for burn patients with obesity indicate additional factors at play. One possible explanation could lie in determining metabolically healthy versus unhealthy obesity, which necessitates further study.
Methods: A retrospective study was conducted using the Cerner Health Facts® Database. Deidentified patient data from 2014 to 2018 with second or third-degree burn injuries were retrieved. A moderator analysis was conducted to determine if the association between increased body mass index (BMI) and mortality is moderated by baseline glucose level, a surrogate marker associated with metabolically unhealthy obesity.
Results: The study included 4682 adult burn patients. BMI alone was not associated with higher mortality (β = 0.106, p = 0.331). Moderation analysis revealed that baseline glucose level significantly modulated the impact of BMI on burn-related obesity; patients with higher BMI and higher baseline blood glucose levels had higher mortality than those with lower baseline blood glucose levels (β = 0.277, p = 0.009). These results remained unchanged after adjusting for additional covariates (β = 0.285, p = 0.025) and inthe sensitivity analysis.
Conclusions: Increased baseline glucose levels indicate increased mortality in obese patients with burn injuries, emphasizing the differentiation between metabolically unhealthy versus healthy obesity.
Competing Interests: Declaration of Competing Interest No conflicts of interest, financial or personal relationships to disclose.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: