Using the Infant Sibling-Design to Explore Associations Between Autism and ADHD Traits in Probands and Temperament in the Younger Siblings.

Autor: Andersson Konke L; Department of Psychology, Uppsala University, Box 1225, 751 42, Uppsala, Sweden. linn.andersson.konke@psyk.uu.se., Falck-Ytter T; Department of Women's and Children's Health, Karolinska Institutet Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.; Stockholm Health Care Services, Stockholm County Council, CAP Research Centre, Stockholm, Sweden.; Development and Neurodiversity Lab (DIVE), Department of Psychology, Uppsala University, Uppsala, Sweden.; The Swedish Collegium for Advanced Study (SCAS), Uppsala, Sweden., Jones EJH; Center for Brain and Cognitive Development, Birkbeck, University of London, London, UK., Goodwin A; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Brocki K; Department of Psychology, Uppsala University, Box 1225, 751 42, Uppsala, Sweden.
Jazyk: angličtina
Zdroj: Journal of autism and developmental disorders [J Autism Dev Disord] 2024 Sep; Vol. 54 (9), pp. 3262-3273. Date of Electronic Publication: 2023 Jun 24.
DOI: 10.1007/s10803-023-06047-x
Abstrakt: The purpose of the current study was to use the infant sibling design to explore whether proband traits of autism and ADHD could provide information about their infant sibling's temperament. This could help us to gain information about the extent to which infant temperament traits are differentially associated with autism and ADHD traits. We used parent-ratings of autistic traits and ADHD traits (CRS-3) in older siblings diagnosed with autism (age range 4 to 19 years), and their infant siblings' temperament traits (IBQ) at 9 months of age in 216 sibling pairs from two sites (BASIS, UK, and EASE, Sweden) to examine associations across siblings. We found specific, but modest, associations across siblings after controlling for sex, age, developmental level and site. Proband autistic traits were specifically related to low levels of approach in the infant siblings, with infant developmental level explaining part of the variance in infant approach. Proband ADHD traits were specifically related to high levels of infant activity even after controlling for covariates. Our findings suggest that proband traits of autism and ADHD carry information for infant sibling's temperament, indicating that inherited liability may influence early emerging behaviours in infant siblings. The impact of sex, age, developmental level and site are discussed.
(© 2023. The Author(s).)
Databáze: MEDLINE
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