The bioengineered and multifunctional nanoparticles in pancreatic cancer therapy: Bioresponisive nanostructures, phototherapy and targeted drug delivery.

Autor: Saadh MJ; Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan; Applied Science Research Center. Applied Science Private University, Amman, Jordan., Baher H; Department of Radiology and Ultrasonography Techniques, College of Medical Techniques, Al-Farahidi University, Baghdad, Iraq., Li Y; Institute of Electrical Engineering, Yanshan University, Qinhuangdao, 066004, China., Chaitanya M; Department of Pharmacognosy, School of Pharmacy, Lovely Professional University, Phagwara, Punjab, 144001, India., Arias-Gonzáles JL; Department of Social Sciences, Faculty of Social Studies, University of British Columbia, Vancouver, Canada., Allela OQB; Department of Pharmacy, AlNoor University College, Nineveh, Iraq., Mahdi MH; College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq., Carlos Cotrina-Aliaga J; Facultad de Ingeniería, Universidad Peruana Los Andes, Huancayo, Peru., Lakshmaiya N; Department of Mechanical Engineering, Saveetha School of Engineering, SIMATS, Chennai, Tamil Nadu, India., Ahjel S; Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq., Amin AH; Zoology Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt., Gilmer Rosales Rojas G; Universidad Peruana Los Andes, Peru., Ameen F; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia., Ahsan M; Department of Measurememts and Control Systems, Silesian University of Technology, Gliwice, 44-100, Poland. Electronic address: Muhammad.Ahsan@polsl.pl., Akhavan-Sigari R; Department of Neurosurgery, University Medical Center Tuebingen, Germany; Department of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University, Warsaw, Poland.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2023 Sep 15; Vol. 233, pp. 116490. Date of Electronic Publication: 2023 Jun 22.
DOI: 10.1016/j.envres.2023.116490
Abstrakt: The multidisciplinary approaches in treatment of cancer appear to be essential in term of bringing benefits of several disciplines and their coordination in tumor elimination. Because of the biological and malignant features of cancer cells, they have ability of developing resistance to conventional therapies such as chemo- and radio-therapy. Pancreatic cancer (PC) is a malignant disease of gastrointestinal tract in which chemotherapy and radiotherapy are main tools in its treatment, and recently, nanocarriers have been emerged as promising structures in its therapy. The bioresponsive nanocarriers are able to respond to pH and redox, among others, in targeted delivery of cargo for specific treatment of PC. The loading drugs on the nanoparticles that can be synthetic or natural compounds, can help in more reduction in progression of PC through enhancing their intracellular accumulation in cancer cells. The encapsulation of genes in the nanoparticles can protect against degradation and promotes intracellular accumulation in tumor suppression. A new kind of therapy for cancer is phototherapy in which nanoparticles can stimulate both photothermal therapy and photodynamic therapy through hyperthermia and ROS overgeneration to trigger cell death in PC. Therefore, synergistic therapy of phototherapy with chemotherapy is performed in accelerating tumor suppression. One of the important functions of nanotechnology is selective targeting of PC cells in reducing side effects on normal cells. The nanostructures are capable of being surface functionalized with aptamers, proteins and antibodies to specifically target PC cells in suppressing their progression. Therefore, a specific therapy for PC is provided and future implications for diagnosis of PC is suggested.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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