The role of the male rat infralimbic cortex in distraction analgesia.

Autor: McNabb CT; Bayer US LLC, Medical Affairs, Oncology, 100 Bayer Blvd, Whippany, NJ 07981, United States; The University of Texas at Arlington, Department of Psychology, Life Science Building, Room 313, 501 S Nedderman Dr., Arlington, TX 76013, United States. Electronic address: chris.mcnabb@bayer.com., Salcido CA; The University of Texas at Arlington, Department of Psychology, Life Science Building, Room 313, 501 S Nedderman Dr., Arlington, TX 76013, United States; University of the Incarnate Word, School of Osteopathic Medicine, 7615 Kennedy Hill, Building 1, San Antonio, TX 78235, United States., Argenbright CM; The University of Texas at Arlington, Department of Psychology, Life Science Building, Room 313, 501 S Nedderman Dr., Arlington, TX 76013, United States., Fuchs PN; The University of Texas at Arlington, Department of Psychology, Life Science Building, Room 313, 501 S Nedderman Dr., Arlington, TX 76013, United States.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2023 Aug 24; Vol. 452, pp. 114552. Date of Electronic Publication: 2023 Jun 22.
DOI: 10.1016/j.bbr.2023.114552
Abstrakt: Cognitive interventions, including distraction, have been successfully utilized in the manipulation of experimental pain and the treatment of clinical pain. Attentional diversions can reduce the experience of pain, a phenomenon known as distraction analgesia (DA). Prior research has suggested that variations in stimulus intensity may influence the magnitude of DA. However, the neural substrates of DA remain largely unknown. Converging evidence suggests that the infralimbic cortex (IL) in the brains of rats may contribute to the phenomenon of DA. The function of the rat IL in DA has never been directly investigated, therefore, this study sought to identify the role of the IL at two levels of noxious stimulus intensity among brain-intact and IL lesioned male rats within an established rat model of DA. A distractor object reduced formalin-induced nociceptive behavior in brain-intact rats, and this DA effect was detectable during low- (0.5% formalin) and high-intensity (1% formalin) stimulation. IL lesion resulted in a near-complete elimination of the DA effect and an overall reduction in formalin pain. These results provide the first known evidence that (i) the IL is involved in processing DA in rats, (ii) the IL contributes to formalin-induced nociceptive behavior irrespective of distraction, and (iii) a high-intensity stimulation was generally more susceptible to DA than low-intensity stimulation. These findings may further inform the mechanisms and future development of non-pharmacological strategies to reduce pain.
Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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