Harnessing the power of endogenous pain control mechanisms for novel therapeutics: how might innovations in neuroimaging help?

Autor:	Howard MA; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London., Lawn T; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London., Kowalczyk OS; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London.; The Wellcome Centre for Human Neuroimaging, Institute of Neurology, University College London, London, UK.
Jazyk:	angličtina
Zdroj:	Current opinion in supportive and palliative care [Curr Opin Support Palliat Care] 2023 Sep 01; Vol. 17 (3), pp. 150-155. Date of Electronic Publication: 2023 Jun 22.
DOI:	10.1097/SPC.0000000000000653
Abstrakt:	Purpose of Review: This review explores the potential of using novel imaging approaches to deepen our understanding of descending modulatory mechanisms in pain, focussing on functional magnetic resonance imaging (fMRI) of the spinal cord and novel approaches to combining molecular and fMRI data. This review sheds light on the neural processes involved in pain modulation, paving the way for the development of targeted treatments. Recent Findings: The reviewed literature demonstrates significant advancements in pain research. Recent studies show the potential of using fMRI to investigate the spinal cord's role in pain modulation. Furthermore, novel analytical approaches integrating molecular and fMRI data show promise in elucidating the complex neurobiological processes underlying pain regulation. The main themes explored here include the identification of neurochemical markers associated with pain modulation and the characterisation of neural circuits involved in descending pain control. Summary: A comprehensive understanding of descending modulatory mechanisms in pain can inform the development of novel treatments, targeting dysfunction of these key pathways. By leveraging spinal fMRI and integrating molecular data into brain fMRI, researchers can identify potential therapeutic targets throughout the neuraxis. These advances may contribute to the development of personalised medicine approaches, allowing for tailored interventions based on individual pain profiles. (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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