ABO Blood Type and Metabolic Markers in COVID-19 Susceptibility and Severity: A Cross-Sectional Study.

Autor: Arent CO; Graduate Program in Health Sciences, Translational Psychiatry Laboratory, University of Southern Santa Catarina (UNESC), Criciúma, Brazil., Padilha APZ; Graduate Program in Health Sciences, Translational Psychiatry Laboratory, University of Southern Santa Catarina (UNESC), Criciúma, Brazil., Borba LA; Graduate Program in Health Sciences, Translational Psychiatry Laboratory, University of Southern Santa Catarina (UNESC), Criciúma, Brazil., de Azevedo Cardoso T; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada., André MC; Graduate Program in Health Sciences, Translational Psychiatry Laboratory, University of Southern Santa Catarina (UNESC), Criciúma, Brazil., Martinello NS; Graduate Program in Health Sciences, Translational Psychiatry Laboratory, University of Southern Santa Catarina (UNESC), Criciúma, Brazil., Rosa T; Graduate Program in Health Sciences, Translational Psychiatry Laboratory, University of Southern Santa Catarina (UNESC), Criciúma, Brazil., Abelaira HM; Graduate Program in Health Sciences, Translational Psychiatry Laboratory, University of Southern Santa Catarina (UNESC), Criciúma, Brazil., de Moura AB; Graduate Program in Health Sciences, Translational Psychiatry Laboratory, University of Southern Santa Catarina (UNESC), Criciúma, Brazil., Andrade NM; Graduate Program in Health Sciences, Translational Psychiatry Laboratory, University of Southern Santa Catarina (UNESC), Criciúma, Brazil., Bertollo AG; Graduate Program in Biomedical Sciences, Laboratory of Physiology Pharmacology and Psychopathology, Federal University of the Southern Frontier, Chapecó, Brazil., de Oliveira GG; Graduate Program in Biomedical Sciences, Laboratory of Physiology Pharmacology and Psychopathology, Federal University of the Southern Frontier, Chapecó, Brazil., Bagatini MD; Graduate Program in Biomedical Sciences, Laboratory of Physiology Pharmacology and Psychopathology, Federal University of the Southern Frontier, Chapecó, Brazil., Ignácio ZM; Graduate Program in Biomedical Sciences, Laboratory of Physiology Pharmacology and Psychopathology, Federal University of the Southern Frontier, Chapecó, Brazil., Quevedo J; Graduate Program in Health Sciences, Translational Psychiatry Laboratory, University of Southern Santa Catarina (UNESC), Criciúma, Brazil.; Faillace Department of Psychiatry and Behavioral Sciences, Center of Excellence on Mood Disorders, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA., Ceretta LB; Graduate Program in Public Health, University of Southern Santa Catarina (UNESC), Criciúma, Brazil., Réus GZ; Graduate Program in Health Sciences, Translational Psychiatry Laboratory, University of Southern Santa Catarina (UNESC), Criciúma, Brazil.
Jazyk: angličtina
Zdroj: Metabolic syndrome and related disorders [Metab Syndr Relat Disord] 2023 Aug; Vol. 21 (6), pp. 335-344. Date of Electronic Publication: 2023 Jun 23.
DOI: 10.1089/met.2023.0022
Abstrakt: Background and Aims: To evaluate the effect of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus on the function and metabolic changes, as well as the relationship of the virus with blood groups. Methods and Results: This cross-sectional study included a matched sample of adult individuals with coronavirus disease 2019 (COVID-19) ( n  = 114) or without (controls; n  = 236). Blood samples were collected and processed for triglycerides (TGs), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, and blood typing analysis. The results showed that subjects with COVID-19 had higher TG and lower HDL-C levels compared with the control group. As for blood typing, the risk of COVID-19 was higher in subjects with blood group A than in those with blood group B and in those with other blood groups. In addition, an association of COVID-19 with blood type and Rh A- was observed. When related to the severity of COVID-19 symptoms, blood type A was more protective against moderate/severe symptoms compared with blood type O. In addition, individuals with blood type O were 2.90 times more likely to have symptoms moderate/severe symptoms of COVID-19 than those with other blood groups and individuals with type A blood were less likely to have severe/moderate symptoms of COVID-19 compared with individuals without type A blood. Conclusion: The results suggest that blood type may play a role in susceptibility to SARS-CoV-2 infection and add evidence that infection with the novel coronavirus may be associated with changes in lipid metabolism.
Databáze: MEDLINE