Comparative efficacy of chemical and botanical pediculicides in Thailand and 4% dimeticone against head louse, Pediculus humanus capitis.

Autor: Yingklang M; Faculty of Public Health, Burapha University, Chonburi, Thailand., Gordon CN; Department of Medical Sciences, Faculty of Allied Health Sciences, Burapha University, Chonburi, Chonburi Province, Thailand., Jaidee PH; Faculty of Public Health, Burapha University, Chonburi, Thailand., Thongpon P; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Pinlaor S; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Jun 23; Vol. 18 (6), pp. e0287616. Date of Electronic Publication: 2023 Jun 23 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0287616
Abstrakt: Head louse infestations remain a global public-health concern due to increased resistance of lice to artificial pediculicides. In Thailand, there is a lack of comparative data on the current efficacy of pediculicides for treating head lice. In this study, we explored the status of botanical and toxic synthetic pediculicides with that of 4% dimeticone liquid gel for treating head lice in Thailand. The ex-vivo pediculicidal activity of various pediculicidal shampoos available at drugstores in Thailand was assessed and compared with that of 4% dimeticone liquid gel. The shampoos chosen were based on active ingredients toxic to lice (1% permethrin, 0.6% carbaryl, 0.15% Stemona root crude extract, or mixed plant extracts), whereas dimeticone acts physically on lice. We found that exposure to 4% dimeticone liquid gel following the manufacturer's instructions completely killed 100% of head lice in 15 min, whereas other pediculicide products failed to kill the great majority of head lice, whether treatment was for 10 min (resulting in 0% to 50.0% mortality) or 30 min (resulting in 17.0% to 60.0% mortality). We also extended a clinical assessment to confirm the efficacy of 1% permethrin for treating head lice in infested schoolchildren. In this clinical assessment, none of the 26 children treated with 1% permethrin shampoo achieved a cure after two applications. These results highlight that 4% dimeticone demonstrated a higher ex-vivo pediculicidal efficacy compared to both chemical and botanical pediculicides in Thailand. Conversely, 1% permethrin showed low efficacy in both laboratory and clinical assessments. Given its physical mode of action, 4% dimeticone merits consideration as an alternative treatment option for lice in Thailand, particularly in cases where treatment with toxic pediculicides has proven ineffective.
Competing Interests: The authors declare that there is no conflict of interest. Any mention of the trademark in this document is purely informational and is not meant to be used for profit or to infringe upon the legal rights of the trademark’s owner. This article is simply distributed for scientific purpose.
(Copyright: © 2023 Yingklang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje