Say 'No' to Cancer and 'Yes' to Cranberry: The Role of Cranberry Extract in Inhibition of Growth of Lung Adenocarcinoma Cells.

Autor:	Zhao L; Department of Respiratory Medicine, the Second People's Hospital of Hefei and Hefei Hospital, Affiliated to Anhui Medical University, Hefei, P.R. China., Kaser E; The Department of Microbiology, Immunology and Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, U.S.A., Lequio M; The Department of Microbiology, Immunology and Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, U.S.A.; The Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A.; Ellis Fischel Cancer Center, University of Missouri School of Medicine, Columbia, MO, U.S.A., D'Mello K; The Department of Microbiology, Immunology and Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, U.S.A.; The Department of Emergency Medicine, University of Texas Health Science Center at San Antonio - UT Health San Antonio, San Antonio, TX, U.S.A., Xiao H; The Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A.; The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, P.R. China., Luechtefeld HD; The Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A., Mayberry TG; The Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A., Bai Q; The Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A., Wakefield MR; The Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A.; Ellis Fischel Cancer Center, University of Missouri School of Medicine, Columbia, MO, U.S.A., Fang Y; The Department of Microbiology, Immunology and Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, IA, U.S.A.; yuijiang.fang@dmu.edu.; The Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A.; Ellis Fischel Cancer Center, University of Missouri School of Medicine, Columbia, MO, U.S.A.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2023 Jul; Vol. 43 (7), pp. 2933-2939.
DOI:	10.21873/anticanres.16464
Abstrakt:	Background/aim: Lung cancer is the leading cause of mortality due to cancer death. Treatment of lung adenocarcinoma (LUAD) is still challenging. Cranberries contain many rich bioactive components that may help fight cancer. The action of cranberry against some cancer types has been reported, however, its role in lung cancer has only been investigated in large-cell lung cancer. In this study, we expanded current research on the role of cranberry in LUAD. Materials and Methods: A549 LUAD cancer cells were treated with commercial cranberry extract (CE). Proliferation of A549 cells was measured with a clonogenic survival assay and quick proliferation assay. Caspase-3 activity was used to evaluate apoptosis of A549 cells. Reverse transcriptase-polymerase chain reaction was conducted to investigate the possible molecular mechanisms involved in the action of CE. Results: Treatment of LUAD with CE reduced the percentage of A549 colonies. This was consistent with the decrease in the optic density of cancer cells after treatment with CE. Caspase-3 activity increased after treatment with CE. The anti-proliferative effect of CE on A549 cells correlated with reduced expression of pro-proliferation molecules cyclin E, cyclin-dependent kinase 2 (CDK2) and CDK4. The pro-apoptotic effect of CE on A549 cells correlated with the reduced expression of the anti-apoptotic molecule caspase 8 and FADD-like apoptosis regulator (FLIP). Conclusion: CE had an inhibitory effect on the growth of LUAD cells by modulation of both pro-proliferative and anti-apoptotic molecules. Our research hopes to guide future treatment options for LUAD. (Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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