Pattern classification based on the amygdala does not predict an individual's response to emotional stimuli.

Autor: Varkevisser T; University Medical Center, Utrecht, The Netherlands.; Brain Research and Innovation Center, Ministry of Defence, Utrecht, The Netherlands.; Utrecht University, Utrecht, The Netherlands., Geuze E; University Medical Center, Utrecht, The Netherlands.; Brain Research and Innovation Center, Ministry of Defence, Utrecht, The Netherlands., van den Boom MA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Department of Neurology and Neurosurgery, University Medical Center, Utrecht, The Netherlands., Kouwer K; Department of Biological and Medical Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway., van Honk J; Utrecht University, Utrecht, The Netherlands.; University of Cape Town, Cape Town, South Africa., van Lutterveld R; University Medical Center, Utrecht, The Netherlands.; Brain Research and Innovation Center, Ministry of Defence, Utrecht, The Netherlands.
Jazyk: angličtina
Zdroj: Human brain mapping [Hum Brain Mapp] 2023 Aug 15; Vol. 44 (12), pp. 4452-4466. Date of Electronic Publication: 2023 Jun 23.
DOI: 10.1002/hbm.26391
Abstrakt: Functional magnetic resonance imaging (fMRI) studies have often recorded robust univariate group effects in the amygdala of subjects exposed to emotional stimuli. Yet it is unclear to what extent this effect also holds true when multi-voxel pattern analysis (MVPA) is applied at the level of the individual participant. Here we sought to answer this question. To this end, we combined fMRI data from two prior studies (N = 112). For each participant, a linear support vector machine was trained to decode the valence of emotional pictures (negative, neutral, positive) based on brain activity patterns in either the amygdala (primary region-of-interest analysis) or the whole-brain (secondary exploratory analysis). The accuracy score of the amygdala-based pattern classifications was statistically significant for only a handful of participants (4.5%) with a mean and standard deviation of 37% ± 5% across all subjects (range: 28-58%; chance-level: 33%). In contrast, the accuracy score of the whole-brain pattern classifications was statistically significant in roughly half of the participants (50.9%), and had an across-subjects mean and standard deviation of 49% ± 6% (range: 33-62%). The current results suggest that the information conveyed by the emotional pictures was encoded by spatially distributed parts of the brain, rather than by the amygdala alone, and may be of particular relevance to studies that seek to target the amygdala in the treatment of emotion regulation problems, for example via real-time fMRI neurofeedback training.
(© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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