Neurological diagnoses in hospitalized COVID-19 patients during the B.1.1.529 surge.

Autor: Kim CY; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA., Sardar Z; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA., Ayele BA; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA., Fleck-Derderian S; United States Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Barrett CE; United States Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Sun Y; Department of Biostatistics, Columbia University, New York, New York, USA., Clague M; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA., Hurst HA; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA., Boruah A; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA.; Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Zucker J; Department of Infectious Disease, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA., Maddox R; United States Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Sejvar J; United States Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Thakur KT; Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA.
Jazyk: angličtina
Zdroj: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2023 Aug; Vol. 10 (8), pp. 1433-1441. Date of Electronic Publication: 2023 Jun 23.
DOI: 10.1002/acn3.51833
Abstrakt: Objective: Emerging variants and sublineages of SARS-CoV-2 have differing disease severity, transmissibility, and immune evasion. The neurological conditions associated with the original strain of SARS-CoV-2 are well established. Our study assessed the neurological presentations specific to hospitalized patients during the B.1.1.529 (Omicron) variant surge in New York City.
Methods: A total of 178 cases with positive RT-PCR result within 6 weeks before admission, and subsequent development of select neurological conditions during the SARS-CoV-2 B.1.1.529 (Omicron) surge between December 1, 2021 and February 28, 2022, were included from 12,800 SARS-CoV-2-positive hospital admissions. Clinical data from acute hospitalizations were compared to findings of inpatient neurological cases with COVID-19 infections from the initial surge in NYC in the same hospital system.
Results: Compared to SARS-CoV-2 infections of the original strain, COVID-19 cases hospitalized during the Omicron surge (B.1.1.529) were associated with incidental and/or asymptomatic COVID-19 cases (96, 53.9%) and an increased incidence of pre-existing neurological and immunocompromising conditions. Encephalopathy, seizures, and stroke remained the most prevalent neurological conditions identified in hospitalized COVID-19 cases during the study period, reflecting a similar distribution of neurological presentations associated with the original strain.
Interpretation: In our cohort of 178 admitted SARS-CoV-2-positive patients with select neurological conditions during the Omicron B.1.1.529 surge, 54% of COVID-19 cases were considered incidental and/or asymptomatic, and the identified neurological conditions resembled those associated with the original SARS-CoV-2 strain. Further studies characterizing neurological presentation in Omicron sublineages and other variants are warranted in an ongoing COVID-19 pandemic.
(© 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
Databáze: MEDLINE
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