Silicosis and tuberculosis: A systematic review and meta-analysis.

Autor:	Jamshidi P; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Center of Public Health, Environmental and Occupational Hazards Control, Shahid Beheshti University of Medical Science, Tehran, Iran., Danaei B; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Arbabi M; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mohammadzadeh B; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Khelghati F; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Akbari Aghababa A; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Nayebzade A; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Shahidi Bonjar AH; Researcher at the National Institute for Medical Research Development (NIMAD), Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran.; Clinician Scientist of Dental Materials and Restorative Dentistry, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Centis R; Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy., Sotgiu G; Clinical Epidemiology and Medical Statistics Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, Italy., Nasiri MJ; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Migliori GB; Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy.
Jazyk:	angličtina
Zdroj:	Pulmonology [Pulmonology] 2025 Dec 31; Vol. 31 (1), pp. 2416791. Date of Electronic Publication: 2024 Oct 24.
DOI:	10.1016/j.pulmoe.2023.05.001
Abstrakt:	Introduction: Silicosis mostly happens in workers with high silica exposure and may accompany the development of various diseases like tuberculosis, cancer, or autoimmune diseases. The term silico-tuberculosis describes a condition in which an individual is affected by both silicosis and tuberculosis at the same time. This systematic review and meta-analysis study was conducted to evaluate the risk of tuberculosis in silicosis patients and individuals exposed to silica dust. Methods: We performed a systematic search for relevant studies up to 6 September 2022 using PubMed/ Medline, and Embase with the following keywords in titles or abstracts: "silicosis" OR "silicoses" OR "pneumoconiosis" OR "pneumoconioses" AND "tuberculosis". Cohort and case-control studies containing relevant and original information about tuberculosis infection in silicosis patients were included for further analysis. Pooled estimates and 95% confidence intervals (CI) for the relative risk of tuberculosis in individuals with silicosis compared to those without; these were evaluated using the random effects model due to the estimated heterogeneity of the true effect sizes. Results: Out of 5352 potentially relevant articles, 7 studies were eligible for systematic review, of which 4 cohort studies were included for meta-analysis. The total population of all studies was 5884, and 90.63% were male. The mean age of participants was 47.7 years. Our meta-analysis revealed a pooled risk ratio of 1.35 (95%CI 1.18-1.53, I 2 : 94.30%) which means an increased risk of silicosis patients and silica-exposed individuals to tuberculosis infection. Conclusion: Silicosis and silica dust exposure increase the risk of tuberculosis. Therefore, we suggest that individuals with long-time silica exposure, like mine workers, be routinely considered for both silicosis and tuberculosis screening programs.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu