Input density tunes Kenyon cell sensory responses in the Drosophila mushroom body.

Autor:	Ahmed M; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Rajagopalan AE; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Pan Y; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Li Y; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48104, USA., Williams DL; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Pedersen EA; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Thakral M; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Previero A; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA., Close KC; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA., Christoforou CP; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA., Cai D; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48104, USA; Biophysics LS&A, University of Michigan, Ann Arbor, MI 48109, USA; Michigan Neuroscience Institute Affiliate, University of Michigan, Ann Arbor, MI 48109, USA., Turner GC; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA., Clowney EJ; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA; Michigan Neuroscience Institute Affiliate, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: jclowney@umich.edu.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2023 Jul 10; Vol. 33 (13), pp. 2742-2760.e12. Date of Electronic Publication: 2023 Jun 21.
DOI:	10.1016/j.cub.2023.05.064
Abstrakt:	The ability to discriminate sensory stimuli with overlapping features is thought to arise in brain structures called expansion layers, where neurons carrying information about sensory features make combinatorial connections onto a much larger set of cells. For 50 years, expansion coding has been a prime topic of theoretical neuroscience, which seeks to explain how quantitative parameters of the expansion circuit influence sensory sensitivity, discrimination, and generalization. Here, we investigate the developmental events that produce the quantitative parameters of the arthropod expansion layer, called the mushroom body. Using Drosophila melanogaster as a model, we employ genetic and chemical tools to engineer changes to circuit development. These allow us to produce living animals with hypothesis-driven variations on natural expansion layer wiring parameters. We then test the functional and behavioral consequences. By altering the number of expansion layer neurons (Kenyon cells) and their dendritic complexity, we find that input density, but not cell number, tunes neuronal odor selectivity. Simple odor discrimination behavior is maintained when the Kenyon cell number is reduced and augmented by Kenyon cell number expansion. Animals with increased input density to each Kenyon cell show increased overlap in Kenyon cell odor responses and become worse at odor discrimination tasks. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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