Individual differences in T1w/T2w ratio development during childhood.

Autor:	Boroshok AL; Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: boroshok@sas.upenn.edu., McDermott CL; Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA., Fotiadis P; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA., Park AT; Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA., Tooley UA; Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA; Department of Psychiatry, Washington University in St. Louis, USA; Department of Neurology, Washington University in St. Louis, USA., Gataviņš MM; Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA., Tisdall MD; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bassett DS; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA; Department of Electrical & Systems Engineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA; Department of Physics & Astronomy, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Santa Fe Institute, Santa Fe, NM, USA., Mackey AP; Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.
Jazyk:	angličtina
Zdroj:	Developmental cognitive neuroscience [Dev Cogn Neurosci] 2023 Aug; Vol. 62, pp. 101270. Date of Electronic Publication: 2023 Jun 16.
DOI:	10.1016/j.dcn.2023.101270
Abstrakt:	Myelination is a key developmental process that promotes rapid and efficient information transfer. Myelin also stabilizes existing brain networks and thus may constrain neuroplasticity, defined here as the brain's potential to change in response to experiences rather than the canonical definition as the process of change. Characterizing individual differences in neuroplasticity may shed light on mechanisms by which early experiences shape learning, brain and body development, and response to interventions. The T1-weighted/T2-weighted (T1w/T2w) MRI signal ratio is a proxy measure of cortical microstructure and thus neuroplasticity. Here, in pre-registered analyses, we investigated individual differences in T1w/T2w ratios in children (ages 4-10, n = 157). T1w/T2w ratios were positively associated with age within early-developing sensorimotor and attention regions. We also tested whether socioeconomic status, cognition (crystallized knowledge or fluid reasoning), and biological age (as measured with molar eruption) were related to T1w/T2w signal but found no significant effects. Associations among T1w/T2w ratios, early experiences, and cognition may emerge later in adolescence and may not be strong enough to detect in moderate sample sizes. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu