Examining albumin as a bioindicator of healing capability in patients with diabetic foot ulcers: a retrospective review.

Autor:	Vlad LG; Wound Care and Hyperbaric Center, Atrium Health Wake Forest Baptist, Winston-Salem, NC., Grosser JA; Wake Forest University School of Medicine, Winston-Salem, NC., Dodenhoff KA; Department of Family Medicine, Atrium Health Wake Forest Baptist, Winston-Salem, NC., Peoples AE; Wake Forest University School of Medicine, Winston-Salem, NC., Aguilo-Seara G; Department of General Surgery, Atrium Health Wake Forest Baptist, Winston-Salem, NC., Molnar JA; Wound Care and Hyperbaric Center, Department of Plastic and Reconstructive Surgery, Atrium Health Wake Forest Baptist, Winston-Salem, NC.
Jazyk:	angličtina
Zdroj:	Wounds : a compendium of clinical research and practice [Wounds] 2023 Jun; Vol. 35 (6), pp. E193-E196.
DOI:	10.25270/wnds/23012
Abstrakt:	Introduction: Identifying a bioindicator of healing capacity would be beneficial in guiding treatment of and reducing morbidity in patients with DFU. Hypoalbuminemia is a well-established risk factor for amputation and, thus, a promising candidate. Objective: This study was conducted to examine whether albumin values over a 12-week treatment course for DFU correlated with ulcer size and outcomes. Materials and Methods: A retrospective review was conducted of 793 patients who presented to the Atrium Health Wake Forest Baptist Wound Care and Hyperbaric Center between 2010 and 2022. Sixty-two patients met the inclusion criteria. Albumin values and wound size data were collected monthly over a 12-week treatment course. Results: Initial albumin values were not significantly different between patients healed by 12 weeks compared with nonhealed patients. Healed proportion and average initial ulcer size in patients with at least 1 hypoalbuminemia value (<3.0 g/dL) were not significantly different from those in patients with normal albumin levels. Patients who trended from normoalbuminemia to hypoalbuminemia displayed significantly increased wound sizes compared to patients with albumin changes within the normal range (0.04 cm² and -1.17 cm², respectively; P < .05). Monthly changes in albumin correlated poorly with wound healing (r = 0.144, P = .240), and large negative albumin trends (>0.5 g/dL per month) did not correlate with increased wound sizes compared with stable or positive trends. Conclusion: Albumin's utility as a bioindicator of short-term healing capability is limited to below-normal values.
Databáze:	MEDLINE
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