Consultations in Eye Pathology: Experience at an Ophthalmology Specialty Hospital.

Autor:	Milman T; From the Department of Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania (Milman, Gonzalez Martinez, Eagle).; the Department of Pathology, Anatomy, and Cell Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania (Milman)., Martinez OGG; From the Department of Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania (Milman, Gonzalez Martinez, Eagle)., Calotti M; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania (Calotti)., Henry RK; the Institute of Ophthalmology and Visual Science, Rutgers University, Newark, New Jersey (Henry)., Eagle RC Jr; From the Department of Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania (Milman, Gonzalez Martinez, Eagle).
Jazyk:	angličtina
Zdroj:	Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2024 Dec 01; Vol. 148 (12), pp. 1279-1291.
DOI:	10.5858/arpa.2022-0507-RA
Abstrakt:	Context.—: Ophthalmic pathology is a discipline that relies heavily on a knowledge of clinical ophthalmology. The diagnosis of ocular and periocular lesions can be challenging because some lesions and diseases are unique to this region, whereas others may demonstrate site-specific differences from nonocular counterparts. Because of these challenges, ocular and periocular biopsies are frequently referred to specialized ophthalmic pathology centers for second-opinion diagnoses. Objective.—: To analyze the referral patterns, diagnostic challenges, and diagnostic discrepancies for second-opinion referrals at a dedicated ophthalmic pathology laboratory with an emphasis on lesions of special interest in ophthalmic pathology. Data Sources.—: Data sources included the pathology records of all slides and blocks received in consultation at the referral eye pathology center between December 1, 2015, and December 1, 2022, the personal experience of senior authors, and published peer-reviewed literature. Conclusions.—: Corneal, intraocular, and conjunctival biopsies are the most common types of cases received in consultation without the referring pathologist's diagnosis, likely reflecting diagnostic challenges. Degenerative intraocular processes occasionally raise concern for a neoplasm. Conjunctival melanocytic lesions are the most common conjunctival biopsies referred for second-opinion diagnosis and require careful tissue sampling and clinical-pathologic correlation. Careful clinical-pathologic correlation, a high level of suspicion, and adequate sampling also are required for the accurate diagnosis of periocular sebaceous carcinoma. The diagnostic discrepancies involving uveal, retinal, conjunctival, eyelid, and temporal artery biopsies are most likely to adversely influence patient management and possible outcome. Such specimens may benefit from referral to specialized ophthalmic pathology laboratories. Competing Interests: The authors have no relevant financial interest in the products or companies described in this article. (© 2024 College of American Pathologists.)
Databáze:	MEDLINE
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