Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach.

Autor:	Perrin ME; Joliot Institute, Commissariat à l'énergie Atomique (CEA), Direction de la Recherche Fondamentale (DRF), CEA Saclay, 91191 Gif-sur-Yvette, France. francoise.ochsenbein@cea.fr.; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, 91190 Gif-sur-Yvette, France., Li B; Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, Institut Européen de Chimie et Biologie, F-33600 Pessac, France. g.guichard@iecb.u-bordeaux.fr., Mbianda J; Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, Institut Européen de Chimie et Biologie, F-33600 Pessac, France. g.guichard@iecb.u-bordeaux.fr., Bakail M; Joliot Institute, Commissariat à l'énergie Atomique (CEA), Direction de la Recherche Fondamentale (DRF), CEA Saclay, 91191 Gif-sur-Yvette, France. francoise.ochsenbein@cea.fr.; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, 91190 Gif-sur-Yvette, France., André C; Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, Institut Européen de Chimie et Biologie, F-33600 Pessac, France. g.guichard@iecb.u-bordeaux.fr., Moal G; Joliot Institute, Commissariat à l'énergie Atomique (CEA), Direction de la Recherche Fondamentale (DRF), CEA Saclay, 91191 Gif-sur-Yvette, France. francoise.ochsenbein@cea.fr.; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, 91190 Gif-sur-Yvette, France., Legrand P; Synchrotron SOLEIL, L'Orme des Merisiers, 91190 Gif-sur-Yvette, France., Ropars V; Joliot Institute, Commissariat à l'énergie Atomique (CEA), Direction de la Recherche Fondamentale (DRF), CEA Saclay, 91191 Gif-sur-Yvette, France. francoise.ochsenbein@cea.fr.; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, 91190 Gif-sur-Yvette, France., Douat C; Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, Institut Européen de Chimie et Biologie, F-33600 Pessac, France. g.guichard@iecb.u-bordeaux.fr., Ochsenbein F; Joliot Institute, Commissariat à l'énergie Atomique (CEA), Direction de la Recherche Fondamentale (DRF), CEA Saclay, 91191 Gif-sur-Yvette, France. francoise.ochsenbein@cea.fr.; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, 91190 Gif-sur-Yvette, France., Guichard G; Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, Institut Européen de Chimie et Biologie, F-33600 Pessac, France. g.guichard@iecb.u-bordeaux.fr.
Jazyk:	angličtina
Zdroj:	Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Jul 11; Vol. 59 (56), pp. 8696-8699. Date of Electronic Publication: 2023 Jul 11.
DOI:	10.1039/d3cc01891a
Abstrakt:	In the search for foldamer inhibitors of the histone chaperone ASF1, we explored the possibility of substituting four α-residues (≈one helix turn) by 3-urea segments and scanned the sequence of a short α-helical peptide known to bind ASF1. By analysing the impact of the different foldamer replacements within the peptide chain, we uncovered new binding modes of the peptide-urea chimeras to ASF1.
Databáze:	MEDLINE
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