Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents.

Autor:	Peña-Corona SI; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico., Hernández-Parra H; Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, Mexico., Bernal-Chávez SA; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico., Mendoza-Muñoz N; Facultad de Ciencias Químicas, Universidad de Colima, Coquimatlán, Mexico., Romero-Montero A; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico., Del Prado-Audelo ML; Escuela de Ingeniería y Ciencias, Tecnologico de Monterrey, Monterrey, Mexico., Cortés H; Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, Mexico., Ateşşahin DA; Department of Plant and Animal Production, Baskil Vocational School, Fırat University, Elazıg, Türkiye., Habtemariam S; Pharmacognosy Research and Herbal Analysis Services UK, University of Greenwich, London, Kent, United Kingdom., Almarhoon ZM; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia., Abdull Razis AF; Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia.; Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia., Modu B; Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia.; Department of Biochemistry, Faculty of Science, University of Maiduguri, Maiduguri, Nigeria., Sharifi-Rad J; Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador., Leyva-Gómez G; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2023 Jun 06; Vol. 14, pp. 1206334. Date of Electronic Publication: 2023 Jun 06 (Print Publication: 2023).
DOI:	10.3389/fphar.2023.1206334
Abstrakt:	Being the first or second cause of death worldwide, cancer represents the most significant clinical, social, and financial burden of any human illness. Despite recent progresses in cancer diagnosis and management, traditional cancer chemotherapies have shown several adverse side effects and loss of potency due to increased resistance. As a result, one of the current approaches is on with the search of bioactive anticancer compounds from natural sources. Neopeltolide is a marine-derived macrolide isolated from deep-water sponges collected off Jamaica's north coast. Its mechanism of action is still under research but represents a potentially promising novel drug for cancer therapy. In this review, we first illustrate the general structural characterization of neopeltolide, the semi-synthetic derivatives, and current medical applications. In addition, we reviewed its anticancer properties, primarily based on in vitro studies, and the possible clinical trials. Finally, we summarize the recent progress in the mechanism of antitumor action of neopeltolide. According to the information presented, we identified two principal challenges in the research, i) the effective dose which acts neopeltolide as an anticancer compound, and ii) to unequivocally establish the mechanism of action by which the compound exerts its antiproliferative effect. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Peña-Corona, Hernández-Parra, Bernal-Chávez, Mendoza-Muñoz, Romero-Montero, Del Prado-Audelo, Cortés, Ateşşahin, Habtemariam, Almarhoon, Abdull Razis, Modu, Sharifi-Rad and Leyva-Gómez.)
Databáze:	MEDLINE
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