| Autor: |
Kim SH; Department of Urology, Urologic Cancer Center, Research Institute and Hospital of National Cancer Center, Goyang 10408, Republic of Korea., Jeon YJ; Department Statistics, Yonsei University, Seoul 03722, Republic of Korea., Bak JK; National Evidence-Based Healthcare Collaborating Agency (NECA), Seoul 04933, Republic of Korea., Yoo BN; National Evidence-Based Healthcare Collaborating Agency (NECA), Seoul 04933, Republic of Korea., Park JW; Department of Orthopaedic Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seognam 13620, Republic of Korea., Ha YC; Department of Orthopaedic Surgery, Seoul Bumin Hospital, Seoul 07590, Republic of Korea., Lee YK; Department of Orthopaedic Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seognam 13620, Republic of Korea. |
| Abstrakt: |
This study evaluated the effect of androgen deprivation therapy (ADT) on osteoporotic fractures (OF) and its prognostic effect on overall survival in patients with localized or regional prostate cancer (PC) using the Korean National Insurance Dataset. A total of 8883 pairs of 1:1 propensity-score-matched patients with localized or regional PC were retrospectively enrolled between 2007 and 2016. All patients underwent at least 1 year of follow-up to evaluate therapeutic outcomes. Multivariate analysis was performed to determine the prognostic effect of ADT on OF. During a mean follow-up of 47.7 months, 977 (3.43%) patients developed OF, and the incidences of hip, spine, and wrist fractures were significantly different between ADT and non-ADT groups ( p < 0.05). The ADT group had a significantly higher incidence of OF (hazard ratio 2.055, 95% confidence interval 1.747-2.417) than the non-ADT group ( p < 0.05), and the incidence of spine/hip/wrist OF was significantly higher in the ADT group regardless of the PC stage ( p < 0.05). Multivariate analysis failed to show any significant difference in overall survival between the two groups ( p > 0.05). ADT resulted in a significantly higher incidence of OF among patients with localized and regional PC, but the overall survival did not differ between ADT and non-ADT groups. |
