Photophysical characterization of tetrahydroxyphenyl porphyrin Zn(II) and V(IV) complexes: experimental and DFT study.

Autor: Diaz-Uribe C; Grupo de Investigación en Fotoquímica y Fotobiología. Programa de Química. Facultad de Ciencias Básicas, Universidad del Atlántico, 081007, Puerto Colombia, Colombia. carlosdiaz@mail.uniatlantico.edu.co., Rangel D; Grupo de Investigación en Fotoquímica y Fotobiología. Programa de Química. Facultad de Ciencias Básicas, Universidad del Atlántico, 081007, Puerto Colombia, Colombia., Vallejo W; Grupo de Investigación en Fotoquímica y Fotobiología. Programa de Química. Facultad de Ciencias Básicas, Universidad del Atlántico, 081007, Puerto Colombia, Colombia., Valle R; Programa de Biología, Facultad de Ciencias Básicas, Universidad del Atlántico, 081007, Puerto Colombia, Colombia., Hidago-Rosa Y; Departamento de Química Inorgánica, Facultad de Química y Farmacia, Centro de Energía UC, Centro de Investigación en Nanotecnología y Materiales Avanzados CIEN-UC, Pontificia, Universidad Católica de Chile, Avenida Vicuña Mackenna, 4860, Santiago, Chile.; Facultad de Ingeniería, Universidad Finis Terrae, Av. Pedro de Valdivia, 1509, Santiago, Providencia, Chile., Zarate X; Facultad de Ingeniería, Instituto de Ciencias Químicas Aplicadas, Universidad Autónoma de Chile, Av. Pedro de Valdivia 425, Santiago, Chile. ximena.zarate@uautonoma.cl., Schott E; Departamento de Química Inorgánica, Facultad de Química y Farmacia, Centro de Energía UC, Centro de Investigación en Nanotecnología y Materiales Avanzados CIEN-UC, Pontificia, Universidad Católica de Chile, Avenida Vicuña Mackenna, 4860, Santiago, Chile. maschotte@gmail.com.; Millennium Nucleus in Catalytic Processes Towards Sustainable Chemistry (CSC), Santiago, Chile. maschotte@gmail.com.
Jazyk: angličtina
Zdroj: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [Biometals] 2023 Dec; Vol. 36 (6), pp. 1257-1272. Date of Electronic Publication: 2023 Jun 21.
DOI: 10.1007/s10534-023-00514-9
Abstrakt: Photodynamic therapy (PDT) is a promising technique for the treatment of various diseases. In this sense, the singlet oxygen quantum yield (Φ ∆ ) is a physical-chemical property that allows to stablish the applicability of a potential photosensitizers (PS) as a drug for PDT. In the herein report, the Φ ∆ of three photosensitizers was determined: metal-free tetrahydroxyphenyl porphyrin (THPP), THPP-Zn and the THPP-V metal complexes. Their biological application was also evaluated. Therefore, the in vitro study was carried out to assess their biological activity against Escherichia coli. The metal-porphyrin complexes exhibited highest activities against the bacterial strain Escherichia coli. at the highest concentration (175 μg/mL) and show better activity than the free base ligand (salts and blank solution). Results indicated a relation between Φ ∆ and the inhibitory activity against Escherichia coli, thus, whereas higher is the Φ ∆ , higher is the inhibitory activity. The values of the Φ ∆ and the inhibitory activity follows the tendency THPP-Zn > THPP > THPP-V. Furthermore, quantum chemical calculations allowed to gain deep insight into the electronic and optical properties of THPP-Zn macrocycle, which let to verify the most probable energy transfer pathway involved in the singlet oxygen generation.
(© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
Externí odkaz: