Design, Synthesis, Characterization and Computational Studies of Mannich Bases Oxadiazole Derivatives as New Class of Jack Bean Urease Inhibitors.
Autor: | Mutahir S; School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276000, China., Khan MA; School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276000, China., Almehizia AA; Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia., Abouzied AS; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail, 81442, Saudi Arabia.; Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research (NODCAR), Giza, 12553, Egypt., Khalifa NE; Department of pharmaceutics, College of Pharmacy, University of Hail, Hail, 81442, Saudi Arabia.; Department of pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum, 11115, Sudan., Naglah AM; Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia., Deng H; School of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing, 210094, China., Refat MS; Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia., Khojali WMA; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail, 81442, Saudi Arabia.; Department of pharmaceutical chemistry, faculty of pharmacy, Omdurman Islamic University, Omdurman, 14415, Sudan., Huwaimel B; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail, 81442, Saudi Arabia.; Medical and Diagnostic Research Center, University of Hail, Hail, 81442, Saudi Arabia. |
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Jazyk: | angličtina |
Zdroj: | Chemistry & biodiversity [Chem Biodivers] 2023 Aug; Vol. 20 (8), pp. e202300241. Date of Electronic Publication: 2023 Jul 26. |
DOI: | 10.1002/cbdv.202300241 |
Abstrakt: | Mannich bases consisting of 1,3,4-oxadiazole-2-thione (3 a-3 l) bearing various substituents were synthesized and found potent jack bean urease inhibitors. The prepared compounds showed significantly good inhibitory activities with IC (© 2023 Wiley-VHCA AG, Zurich, Switzerland.) |
Databáze: | MEDLINE |
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