Association of polychlorinated biphenyls with vitamin D in female subjects.

Autor: Butler AE; School of Medicine, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen, Bahrain. Electronic address: abutler@rcsi.com., Brennan E; School of Medicine, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen, Bahrain. Electronic address: ebrennan@rcsi.com., Drage DS; School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, West Midlands, B15 2TT, UK; Queensland Alliance for Environmental Health Sciences, The University of Queensland, 39 Kessels Road, Coopers Plains, Qld, 4108, Australia. Electronic address: d.s.drage@bham.ac.uk., Sathyapalan T; Hull York Medical School, University of Hull, UK. Electronic address: Thozhukat.Sathyapalan@hyms.ac.uk., Atkin SL; School of Medicine, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen, Bahrain. Electronic address: satkin@rcsi.com.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2023 Sep 15; Vol. 233, pp. 116465. Date of Electronic Publication: 2023 Jun 19.
DOI: 10.1016/j.envres.2023.116465
Abstrakt: Introduction: Polychlorinated biphenyls (PCBs) are known endocrine disrupters. A potentially causal association of PCBs with vitamin D has been reported. Higher body mass index (BMI) is associated with lower PCB levels whilst the strongest association of PCBs with BMI is in non-obese individuals. Therefore, this study examined the association of PCBs with vitamin D 3 (25(OH)D 3 ) and the active 1,25-dihydrovitamin D 3 (1,25(OH) 2 D 3) in a cohort of non-obese women.
Methods: 58 female participants (age 31.9 ± 4.6 years; BMI 25.7 ± 3.7 kg/m 2 ) had seven indicator PCBs [PCB28, PCB52, PCB101, PCB118, PCB138, PCB153 and PCB180] measured using high resolution gas chromatography, with total PCB level calculated. 25(OH)D 3 and 1,25(OH) 2 D 3 levels were determined by isotope-dilution liquid chromatography tandem mass spectrometry.
Results: In this cohort, vitamin D 3 (25(OH)D 3 ) and 1,25(OH) 2 D 3 levels were 50.7 ± 25.3 nmol/L and 0.05 ± 0.02 ng/ml, respectively. Of those, 28 had vitamin D deficiency [25(OH)D 3 level <20 ng/ml (<50nmol/)]. Total PCBs correlated positively with total group 25(OH)D 3 (r = 0.22, p = 0.04) as did PCB118 (r = 0.25, p = 0.03). Total PCBs did not correlate with total group 1,25(OH) 2 D 3 ; however, PCB180 did correlate positively with 1,25(OH) 2 D 3 (r = 0.34, p = 0.03) as did PCB153 (r = 0.33, p < 0.03), with PCB 28 correlating negatively (r = -0.29, p < 0.04). In the vitamin D deficient subgroup, total PCBs, PCB153 and PCB180 positively correlated with 25(OH)D 3 (p < 0.05). Multilinear regression analysis indicated all associations could be accounted for by BMI.
Conclusion: Though certain PCBs associated with 25(OH)D 3 and 1,25(OH) 2 D 3 , all associations could be accounted for by BMI. This study therefore indicates that the deleterious effects from PCB accumulation are not mediated by effects on 25(OH)D 3 or 1,25(OH) 2 D 3 .
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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