Characteristics of Henle's fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography.

Autor:	Motschi AR; Medical University of Vienna, Center for Medical Physics and Biomedical Engineering, Vienna, Austria., Schwarzhans F; Medical University of Vienna, Center for Medical Statistics, Informatics and Intelligent Systems, Vienna, Austria.; Medical University of Vienna, Department of Clinical Pharmacology, Vienna, Austria., Desissaire S; Medical University of Vienna, Center for Medical Physics and Biomedical Engineering, Vienna, Austria., Steiner S; Medical University of Vienna, Department of Ophthalmology and Optometry, Vienna, Austria., Bogunović H; Medical University of Vienna, Christian Doppler Laboratory for Artificial Intelligence in Retina, Vienna, Austria., Roberts PK; Medical University of Vienna, Department of Ophthalmology and Optometry, Vienna, Austria., Vass C; Medical University of Vienna, Department of Ophthalmology and Optometry, Vienna, Austria., Hitzenberger CK; Medical University of Vienna, Center for Medical Physics and Biomedical Engineering, Vienna, Austria., Pircher M; Medical University of Vienna, Center for Medical Physics and Biomedical Engineering, Vienna, Austria.
Jazyk:	angličtina
Zdroj:	Biomedical optics express [Biomed Opt Express] 2023 May 16; Vol. 14 (6), pp. 2709-2725. Date of Electronic Publication: 2023 May 16 (Print Publication: 2023).
DOI:	10.1364/BOE.485327
Abstrakt:	Using conventional optical coherence tomography (OCT), it is difficult to image Henle fibers (HF) due to their low backscattering potential. However, fibrous structures exhibit form birefringence, which can be exploited to visualize the presence of HF by polarization-sensitive (PS) OCT. We found a slight asymmetry in the retardation pattern of HF in the fovea region that can be associated with the asymmetric decrease of cone density with eccentricity from the fovea. We introduce a new measure based on a PS-OCT assessment of optic axis orientation to estimate the presence of HF at various eccentricities from the fovea in a large cohort of 150 healthy subjects. By comparing a healthy age-matched sub-group (N = 87) to a cohort of 64 early-stage glaucoma patients, we found no significant difference in HF extension but a slightly decreased retardation at about 2° to 7.5° eccentricity from the fovea in the glaucoma patients. This potentially indicates that glaucoma affects this neuronal tissue at an early state. Competing Interests: The authors declare no conflicts of interest. (Published by Optica Publishing Group under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.)
Databáze:	MEDLINE
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