The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory-SARS-CoV-2.

Autor:	Blacksell SD; Mahidol-Oxford Tropical Research Medicine Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Nuffield Department of Medicine Research Building, University of Oxford, Oxford, United Kingdom., Dhawan S; Mahidol-Oxford Tropical Research Medicine Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Kusumoto M; Mahidol-Oxford Tropical Research Medicine Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Le KK; Mahidol-Oxford Tropical Research Medicine Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Summermatter K; Institute for Infectious Diseases, University of Bern, Bern, Switzerland., O'Keefe J; Ministry for Primary Industries, Wellington, New Zealand., Kozlovac J; U.S. Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA., Almuhairi SS; Abu Dhabi Agriculture and Food Safety Authority, Abu Dhabi, United Arab Emirates., Sendow I; Research Center for Veterinary Science, National Research and Innovation Agency, Indonesia., Scheel CM; WHO Collaborating Center for Biosafety and Biosecurity, Office of the Associate Director for Laboratory Science, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Ahumibe A; Nigeria Centre for Disease Control and Prevention, Abuja, Nigeria., Masuku ZM; National Institute for Communicable Diseases of the National Health Laboratory Services, Sandringham, South Africa., Kojima K; Department of Epidemic and Pandemic Preparedness and Prevention, World Health Organization, Geneva, Switzerland., Harper DR; The Royal Institute of International Affairs, London, United Kingdom., Hamilton K; World Organisation for Animal Health (OIE), Paris, France.
Jazyk:	angličtina
Zdroj:	Applied biosafety : journal of the American Biological Safety Association [Appl Biosaf] 2023 Jun 01; Vol. 28 (2), pp. 87-95. Date of Electronic Publication: 2023 Jun 05.
DOI:	10.1089/apb.2022.0039
Abstrakt:	Introduction: The SARS-CoV-2 virus emerged as a novel virus and is the causative agent of the COVID-19 pandemic. It spreads readily human-to-human through droplets and aerosols. The Biosafety Research Roadmap aims to support the application of laboratory biological risk management by providing an evidence base for biosafety measures. This involves assessing the current biorisk management evidence base, identifying research and capability gaps, and providing recommendations on how an evidence-based approach can support biosafety and biosecurity, including in low-resource settings. Methods: A literature search was conducted to identify potential gaps in biosafety and focused on five main sections, including the route of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination strategies. Results: There are many knowledge gaps related to biosafety and biosecurity due to the SARS-CoV-2 virus's novelty, including infectious dose between variants, personal protective equipment for personnel handling samples while performing rapid diagnostic tests, and laboratory-acquired infections. Detecting vulnerabilities in the biorisk assessment for each agent is essential to contribute to the improvement and development of laboratory biosafety in local and national systems. Competing Interests: No competing financial interests exist. (© Stuart D. Blacksell et al. 2023; Published by Mary Ann Liebert, Inc.)
Databáze:	MEDLINE
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