| Autor: |
Rassbach J; Leibniz Institute for Natural Product Research and Infection Biology (Hans-Knöll-Institute), Department Pharmaceutical Microbiology, Friedrich-Schiller-University, Winzerlaer Strasse 2, 07745 Jena, Germany., Merseburger P; Leibniz Institute for Natural Product Research and Infection Biology (Hans-Knöll-Institute), Department Pharmaceutical Microbiology, Friedrich-Schiller-University, Winzerlaer Strasse 2, 07745 Jena, Germany., Wurlitzer JM; Leibniz Institute for Natural Product Research and Infection Biology (Hans-Knöll-Institute), Department Pharmaceutical Microbiology, Friedrich-Schiller-University, Winzerlaer Strasse 2, 07745 Jena, Germany., Binnemann N; Chemical Ecology Group, University of Bremen, Institute of Ecology, Leobener Strasse 5, 28359 Bremen, Germany., Voigt K; Jena Microbial Resource Collection, Leibniz Institute for Natural Product Research and Infection Biology (Hans Knöll Institute), Adolf-Reichwein-Strasse 23, 07745 Jena, Germany.; Friedrich Schiller University, Institute of Microbiology, Neugasse 25, 07743 Jena, Germany., Rohlfs M; Chemical Ecology Group, University of Bremen, Institute of Ecology, Leobener Strasse 5, 28359 Bremen, Germany., Gressler M; Leibniz Institute for Natural Product Research and Infection Biology (Hans-Knöll-Institute), Department Pharmaceutical Microbiology, Friedrich-Schiller-University, Winzerlaer Strasse 2, 07745 Jena, Germany. |
| Abstrakt: |
Early diverging fungi, such as Mortierella alpina , are an emerging source of bioactive peptides. By screening 22 fungal isolates together with precursor-directed biosynthesis, a family of threonine-linked cyclotetradepsipeptides, the cycloacetamides A-F ( 1 - 6 ), was identified. The structure elucidation was conducted using NMR and HR-ESI-MS/MS analyses, and the absolute configuration was determined by Marfey's analysis and total synthesis. Cycloacetamides are not cytotoxic to human cells, while being highly selectively insecticidal against fruit fly larvae. |
