Biological activity of cinnamaldehyde, citronellal, geraniol and anacardic acid on Haemonchus contortus isolates susceptible and resistant to synthetic anthelmintics.

Autor:	Frota GA; Programa de Pós-graduação em Zootecnia, Universidade Estadual Vale do Acaraú - UVA, Sobral, CE, Brasil., Santos VOD; Programa de Pós-graduação em Zootecnia, Universidade Estadual Vale do Acaraú - UVA, Sobral, CE, Brasil., Rodrigues JFV; Programa de Pós-graduação em Microbiologia, Parasitologia e Patologia, Universidade Federal do Paraná - UFPR, Curitiba, PR, Brasil., Oliveira BR; Centro Universitário Inta - UNINTA, Sobral, CE, Brasil., Albuquerque LB; Centro Universitário Inta - UNINTA, Sobral, CE, Brasil., Vasconcelos FRC; Centro Universitário Inta - UNINTA, Sobral, CE, Brasil., Silva AC; Centro Universitário Inta - UNINTA, Sobral, CE, Brasil., Teixeira M; Programa de Pós-graduação em Zootecnia, Universidade Estadual Vale do Acaraú - UVA, Sobral, CE, Brasil.; Programa de Pós-graduação em Microbiologia, Parasitologia e Patologia, Universidade Federal do Paraná - UFPR, Curitiba, PR, Brasil.; Embrapa Caprinos e Ovinos, Sobral, CE, Brasil., Brito ES; Embrapa Alimentos e Territórios, Maceió, AL, Brasil., Santos JMLD; Centro Universitário Inta - UNINTA, Sobral, CE, Brasil., Vieira LDS; Embrapa Caprinos e Ovinos, Sobral, CE, Brasil., Monteiro JP; Programa de Pós-graduação em Zootecnia, Universidade Estadual Vale do Acaraú - UVA, Sobral, CE, Brasil.; Centro Universitário Inta - UNINTA, Sobral, CE, Brasil.; Embrapa Caprinos e Ovinos, Sobral, CE, Brasil.
Jazyk:	angličtina
Zdroj:	Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria [Rev Bras Parasitol Vet] 2023 Jun 19; Vol. 32 (2), pp. e006023. Date of Electronic Publication: 2023 Jun 19 (Print Publication: 2023).
DOI:	10.1590/S1984-29612023027
Abstrakt:	Parasitism by gastrointestinal nematodes is a challenge for small ruminant farming worldwide. It causes productive and economic losses, especially due to parasite resistance to conventional anthelmintics. Natural compounds with antiparasitic activity are a potential alternative for controlling these parasites especially when considering the widespread occurrence of anthelmintic resistance. Our objective was to evaluate the activity of anacardic acid, geraniol, cinnamaldehyde and citronellal on Haemonchus contortus isolates with different levels of anthelmintic resistance profiles. These compounds were tested using egg hatch assays (EHAs), larval development tests (LDTs) as well as LDTs on mini-fecal cultures, on the Haemonchus contortus isolates Kokstad (KOK-resistant to all anthelmintics), Inbred-Strain-Edinburgh (ISE-susceptible to all anthelmintics) and Echevarria (ECH-susceptible to all anthelmintics). Effective concentrations to inhibit 50% (EC50) and 95% (EC95) of egg hatching and larval development were calculated. Results for EHA and LDT for all tested compounds, considering EC50 and EC95 values, showed low variation among the studied isolates with most RF values below 2x. All studied compounds showed efficacy against egg hatching and larval development of H. contortus isolates regardless of anthelmintic resistance profiles. The compounds with the smallest EC50 and EC95 values were cinnamaldehyde and anacardic acid making them promising candidates for future in vivo studies.
Databáze:	MEDLINE
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