Prevalence of MMTV-like sequences in breast cancer samples in Romanian patients-there is a geographic difference compared to the Western world.

Autor: Fekete Z; Oncology-Radiotherapy, Department of Oncology, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. fekete.zsolt@umfcluj.ro.; Institute of Oncology 'Prof Dr. Ion Chiricuță', Radiotherapy III, Cluj-Napoca, Romania. fekete.zsolt@umfcluj.ro., Tertan BO; 'Iuliu Hațieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania., Raduly L; Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Eniu DT; Oncological Surgery and Gynecologic Oncology, Department of Oncology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.; Surgery Department, Institute of Oncology 'Prof Dr. Ion Chiricuță', Cluj-Napoca, Romania., Buiga R; Pathology Department, Institute of Oncology 'Prof Dr. Ion Chiricuță', Cluj-Napoca, Romania., Galatar M; Pathology Department, Institute of Oncology 'Prof Dr. Ion Chiricuță', Cluj-Napoca, Romania., Berindan-Neagoe I; Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Jazyk: angličtina
Zdroj: Infectious agents and cancer [Infect Agent Cancer] 2023 Jun 20; Vol. 18 (1), pp. 39. Date of Electronic Publication: 2023 Jun 20.
DOI: 10.1186/s13027-023-00486-y
Abstrakt: Background: Breast cancer, although the most frequently diagnosed malignant tumor in humans, has a less clear etiology compared to other frequent cancer types. Mouse-mammary tumor virus (MMTV) is involved in breast cancer in mice and dogs and might play a role in the etiology of some breast cancers in humans, since an MMTV-like sequence was identified in 20-40% of breast cancer samples in Western Europe, USA, Australia and some other parts of the world. The purpose of our study was to identify MMTV-like DNA sequences in breast tissue samples from breast cancer patients who underwent curative surgery in our regional academic center in Romania, EU.
Methods: We selected 75 patients with non-metastatic breast cancer treated surgically with curative intent, who did not undergo any neoadjuvant treatment. Out of these patients, 50 underwent radical lumpectomy and 25 modified radical mastectomy. Based on previous reports in the literature we searched using PCR the MMTV-like DNA env sequence in the breast cancer tissue and normal breast tissue obtained from the same patients.
Results: None of the examined samples was positive for MMTV-like target sequences on PCR.
Conclusions: We could not prove that MMTV plays a role in the etiology of breast cancer in our patient group. This finding is similar to those from publications of other geographically related research groups.
(© 2023. The Author(s).)
Databáze: MEDLINE
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