RIG-I expression pattern and cytokine profile in indigenous ducks infected with duck plague virus.

Autor: Chabukdhara P; Department of Veterinary Physiology & Biochemistry, Lakhimpur College of Veterinary Science, Assam Agricultural University, North Lakhimpur, Assam, 787 051, India. Electronic address: pchabukdhara87@aau.ac.in., Kalita DJ; Department of Veterinary Biochemistry, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, 781022, India., Tamuly S; Department of Veterinary Biochemistry, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, 781022, India., Bora DP; Department of Veterinary Microbiology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, 781022, India., Saikia DP; Department of Animal Biotechnology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, 781022, India., Borah S; Department of Veterinary Physiology & Biochemistry, Lakhimpur College of Veterinary Science, Assam Agricultural University, North Lakhimpur, Assam, 787 051, India., Hazorika M; Veterinary Clinical Complex, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, 781022, India., Borah MC; Department of Livestock Production and Management (Biostatistics), College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, 781022, India., Gogoi SM; Department of Veterinary Microbiology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, 781022, India., Deka NJ; Department of Veterinary Biochemistry, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, 781022, India., Gogoi A; Department of Animal Genetics & Breeding, Lakhimpur College of Veterinary Science, Assam Agricultural University, North Lakhimpur, Assam, 787 051, India., Bordoloi G; Department of Veterinary Parasitology, Lakhimpur College of Veterinary Science, Assam Agricultural University, North Lakhimpur, Assam, 787 051, India., Khargharia S; Department of Veterinary Pharmacology & Toxicology, Lakhimpur College of Veterinary Science, Assam Agricultural University, North Lakhimpur, Assam, 787 051, India., Pathak SS; Department of Livestock Production and Management (Poultry Science), Lakhimpur College of Veterinary Science, Assam Agricultural University, North Lakhimpur, Assam, 787 051, India.
Jazyk: angličtina
Zdroj: Microbial pathogenesis [Microb Pathog] 2023 Aug; Vol. 181, pp. 106205. Date of Electronic Publication: 2023 Jun 18.
DOI: 10.1016/j.micpath.2023.106205
Abstrakt: The present study was undertaken to elucidate mRNA expression pattern of RIG-I and serum cytokines profile alterations in indigenous ducks of Assam, India viz. Pati, Nageswari and Cinahanh in response to natural infections of duck plague virus. Field outbreaks of duck plague virus were attended during the study period for collection of tissue and blood samples. The ducks under study were divided into three distinct groups as per health status i.e. healthy, duck plague infected and recovered. Results from the study revealed that RIG-I gene expression was significantly upregulated in liver, intestine, spleen, brain and PBMC of both infected and recovered ducks. However, fold changes in RIG- I gene expression was lower in recovered ducks as compared to infected ones which indicated continued stimulation of RIG-I gene by the latent viruses. Both serum pro and anti-inflammatory cytokines were elevated in infected ducks as compared to healthy and recovered ducks, indicating activation of inflammatory reactions in the ducks due to virus invasion. The results from the study indicated that innate immune components of the infected ducks were stimulated in order to make an attempt to resist the virus from the infected ducks.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. Dhruba Jyoti Kalita reports financial support was provided by Department of Biotechnology, Government of India.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: