Comparison of Medical and Mental Health Sequelae Following Hospitalization for COVID-19, Influenza, and Sepsis.

Autor:	Quinn KL; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto and Ottawa, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, Sinai Health and University Health Network, Toronto, Ontario, Canada.; Temmy Latner Centre for Palliative Care, Toronto, Ontario, Canada., Stukel TA; ICES, Toronto and Ottawa, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada., Huang A; ICES, Toronto and Ottawa, Ontario, Canada., Abdel-Qadir H; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto and Ottawa, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.; Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada., Altaf A; ICES, Toronto and Ottawa, Ontario, Canada., Bell CM; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto and Ottawa, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, Sinai Health and University Health Network, Toronto, Ontario, Canada., Cheung AM; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto and Ottawa, Ontario, Canada., Detsky AS; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, Sinai Health and University Health Network, Toronto, Ontario, Canada., Goulding S; COVID Long-Haulers Canada, Oakville, Ontario, Canada., Herridge M; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto and Ottawa, Ontario, Canada., Ivers N; Women's College Hospital, University of Toronto, Toronto, Ontario, Canada., Lapointe-Shaw L; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto and Ottawa, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, Sinai Health and University Health Network, Toronto, Ontario, Canada., Lapp J; Department of Medicine, Sinai Health and University Health Network, Toronto, Ontario, Canada., McNaughton CD; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto and Ottawa, Ontario, Canada.; Sunnybrook Research Institute, Toronto, Ontario, Canada., Raissi A; Li Ka Shing Knowledge Institute, Unity Health Toronto, Department of Medicine, Toronto, Ontario, Canada.; Unity Health Toronto, Department of Medicine, St Michael's Hospital, Toronto, Ontario, Canada., Rosella LC; ICES, Toronto and Ottawa, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada., Warda N; Department of Medicine, Sinai Health and University Health Network, Toronto, Ontario, Canada., Razak F; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, Unity Health Toronto, Department of Medicine, Toronto, Ontario, Canada.; Unity Health Toronto, Department of Medicine, St Michael's Hospital, Toronto, Ontario, Canada., Verma AA; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, Unity Health Toronto, Department of Medicine, Toronto, Ontario, Canada.; Unity Health Toronto, Department of Medicine, St Michael's Hospital, Toronto, Ontario, Canada.; Temerty Centre for AI Research and Education in Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	JAMA internal medicine [JAMA Intern Med] 2023 Aug 01; Vol. 183 (8), pp. 806-817.
DOI:	10.1001/jamainternmed.2023.2228
Abstrakt:	Importance: People who survive hospitalization for COVID-19 are at risk for developing new cardiovascular, neurological, mental health, and inflammatory autoimmune conditions. It is unclear how posthospitalization risks for COVID-19 compare with those for other serious infectious illnesses. Objective: To compare risks of incident cardiovascular, neurological, and mental health conditions and rheumatoid arthritis in 1 year following COVID-19 hospitalization against 3 comparator groups: prepandemic hospitalization for influenza and hospitalization for sepsis before and during the COVID-19 pandemic. Design, Setting, and Participants: This population-based cohort study included all adults hospitalized for COVID-19 between April 1, 2020, and October 31, 2021, historical comparator groups of people hospitalized for influenza or sepsis, and a contemporary comparator group of people hospitalized for sepsis in Ontario, Canada. Exposure: Hospitalization for COVID-19, influenza, or sepsis. Main Outcome and Measures: New occurrence of 13 prespecified conditions, including cardiovascular, neurological, and mental health conditions and rheumatoid arthritis, within 1 year of hospitalization. Results: Of 379 366 included adults (median [IQR] age, 75 [63-85] years; 54% female), there were 26 499 people who survived hospitalization for COVID-19, 299 989 historical controls (17 516 for influenza and 282 473 for sepsis), and 52 878 contemporary controls hospitalized for sepsis. Hospitalization for COVID-19 was associated with an increased 1-year risk of venous thromboembolic disease compared with influenza (adjusted hazard ratio, 1.77; 95% CI, 1.36-2.31) but with no increased risks of developing selected ischemic and nonischemic cerebrovascular and cardiovascular disorders, neurological disorders, rheumatoid arthritis, or mental health conditions compared with influenza or sepsis cohorts. Conclusions and Relevance: In this cohort study, apart from an elevated risk of venous thromboembolism within 1 year, the burden of postacute medical and mental health conditions among those who survived hospitalization for COVID-19 was comparable with other acute infectious illnesses. This suggests that many of the postacute consequences of COVID-19 may be related to the severity of infectious illness necessitating hospitalization rather than being direct consequences of infection with SARS-CoV-2.
Databáze:	MEDLINE
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