Gradients of neurotransmitter receptor expression in the macaque cortex.

Autor: Froudist-Walsh S; Computational Neuroscience Unit, Faculty of Engineering, University of Bristol, Bristol, UK.; Center for Neural Science, New York University, New York, NY, USA., Xu T; Child Mind Institute, New York, NY, USA., Niu M; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany., Rapan L; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany., Zhao L; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany., Margulies DS; Integrative Neuroscience and Cognition Center, University of Paris Cité, Paris, France., Zilles K, Wang XJ; Center for Neural Science, New York University, New York, NY, USA., Palomero-Gallagher N; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany. n.palomero-gallagher@fz-juelich.de.; Cécile and Oskar Vogt Institute for Brain Research, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. n.palomero-gallagher@fz-juelich.de.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2023 Jul; Vol. 26 (7), pp. 1281-1294. Date of Electronic Publication: 2023 Jun 19.
DOI: 10.1038/s41593-023-01351-2
Abstrakt: Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map of receptor organization across cortical regions is needed. In this study, we used in vitro receptor autoradiography to measure the density of 14 neurotransmitter receptor types in 109 areas of macaque cortex. We integrated the receptor data with anatomical, genetic and functional connectivity data into a common cortical space. We uncovered a principal gradient of receptor expression per neuron. This aligns with the cortical hierarchy from sensory cortex to higher cognitive areas. A second gradient, driven by serotonin 5-HT 1A receptors, peaks in the anterior cingulate, default mode and salience networks. We found a similar pattern of 5-HT 1A expression in the human brain. Thus, the macaque may be a promising translational model of serotonergic processing and disorders. The receptor gradients may enable rapid, reliable information processing in sensory cortical areas and slow, flexible integration in higher cognitive areas.
(© 2023. The Author(s).)
Databáze: MEDLINE
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